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| ^125I粒子治疗对肝癌细胞凋亡及细胞周期的影响 | |
| 引用本文： | 张颖,林军. ^125I粒子治疗对肝癌细胞凋亡及细胞周期的影响[J]. 国外医学(放射医学核医学分册), 2009, 0(4): 193-195 |
| 作者姓名： | 张颖 林军 |
| 作者单位： | 福建医科大学附属第一医院核医学科,福州350005 |
| 基金项目： | 福建省教育厅资助项目（JB：06255） |
| 摘 要： | ^125I粒子低剂量率连续照射肝癌细胞，能明显上调细胞Bax表达，降低Bcl-2表达，同时明显诱导细胞凋亡的发生，且细胞周期发生再分布，照射后细胞被阻滞在对辐射相对敏感的G2-M和S期。研究结果表明，^125I粒子连续照射能够通过诱导凋亡的途径，明显杀伤肿瘤细胞。 |
| 关 键 词： | 肝肿瘤 碘放射性同位素 近距离放射疗法 细胞凋亡 细胞周期 |
Effects of ^125I seed brachytherapy on apoptosis and cell cycle distribution in hepatoma carcinoma cells |
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| ZHA NG Ying,LIN Jun. Effects of ^125I seed brachytherapy on apoptosis and cell cycle distribution in hepatoma carcinoma cells[J]. Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine), 2009, 0(4): 193-195 | |
| Authors: | ZHA NG Ying LIN Jun |
| Affiliation: | ( Department of Nuclear Medicine,First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China ) |
| Abstract: | Continuous irradiation of low dose rate ^125I seed resulted in an increase in the apoptosis and an increased expression of Bax and a decreased expression of Bel-2. The cell-cycle arrest of hepatoma carcinoma cells was induced remarkably. The results demonstrated that low dose rate of continuous ^125I seed irradiation is effective on inducing the damage of the tumor cells. |
| Keywords: | Liver neoplasms Iodine radioisotope Brachytherapy Apoptosis Cell cycle |
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