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| p16和Rb基因产物在非小细胞肺癌的表达 | |
| 引用本文： | Wang X,Li Y,Qin J,Zhao H,Zhao T. p16和Rb基因产物在非小细胞肺癌的表达[J]. 中国肺癌杂志, 2001, 4(1): 63-65 |
| 作者姓名： | Wang X Li Y Qin J Zhao H Zhao T |
| 作者单位： | 1. 天津医科大学病理学教研室 2. 天津医科大学第二医院 3. 天津市胸科医院 |
| 基金项目： | 天津市自然科学基金!(98360 81 1 1 ) |
| 摘 要： | 目的 研究非小细胞肺癌 (NSCLC)中p16、Rb蛋白表达及二者的关系。方法 应用免疫组织化学技术 (SP法 )检测 74例NSCLC和 10例正常肺组织中p16、Rb蛋白的表达情况。结果 p16蛋白在NSCLC的缺失率为 45 .95 % ,显著高于正常肺组织 (P <0 .0 1) ,并与淋巴结转移有密切关系 (P <0 .0 1)。Rb蛋白在NSCLC的缺失率为 2 8.3 8% ,与正常肺组织差异无显著性 (P >0 .0 5 )。p16蛋白与Rb蛋白表达呈负相关 (P <0 .0 5 )。结论 p16缺失与可能NSCLC的发生、转移有密切关系。p16与Rb可能通过负反馈机制相互调节。 |
| 关 键 词： | 非小细胞肺癌 p16 基因 RB 基因 免疫组织化学 |
| 修稿时间： | 2000-07-26 |
The expression of p16 and Rb proteins in non-small cell lung cancer |
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| Wang X,Li Y,Qin J,Zhao H,Zhao T. The expression of p16 and Rb proteins in non-small cell lung cancer[J]. Chinese journal of lung cancer, 2001, 4(1): 63-65 | |
| Authors: | Wang X Li Y Qin J Zhao H Zhao T |
| Affiliation: | Department of Pathology, Tianjin Medical University, Tianjin 300070, P.R.China. |
| Abstract: | Objective To study the expression of p16, Rb proteins and their relationship. Methods The expression of p16, Rb in 74 cases of NSCLC and 10 cases of normal lung tissues were studied by SP immunohistochemical technique. Results p16 protein deletion rate in NSCLC was 45.95%, which was higher than that in normal lung tissue (P<0.01). p16 protein deletion correlated remarkably with lymph node metastasis(P<0.01). Rb protein deletion rate in NSCLC was 28.38%. No significant correlation of Rb deletion rate was found between NSCLC and normal lung tissues (P>0.05). p16 expression showed negative correlation with Rb expression(P<0.05). Conclusion p16 deletion may play an important role in the tumorigenesis and metastasis of NSCLC. There may be a negative feedback pathway between p16 and Rb. |
| Keywords: | Non small cell lung cancer p16 Rb Immunohistochemistry |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |