Direct extraction and assay of collagenase from human osteoarthritic articular cartilage |
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| Authors: | A Blanckaert B Mazières Y Eeckhout G Vaes |
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| Affiliation: | Laboratoire de Pathologie Ostéo-articulaire, CHU Rangueil, Toulouse, France. |
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| Abstract: | ![]()
A method has been developed for the direct extraction of collagenase from small quantities (5 mg) of human osteoarthritic articular cartilage. The enzyme, which was not detected in normal cartilage, was entirely in a latent form and demonstrated typical properties of mammalian collagenase after activation by trypsin. |
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