| βB2晶状体蛋白与白内障 |
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| 引用本文： | 蒋燕,康刚劲,徐曼华,李开明.βB2晶状体蛋白与白内障[J].国际眼科杂志,2016,16(2):261-264. |
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| 作者姓名： | 蒋燕 康刚劲 徐曼华 李开明 |
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| 作者单位： | 四川医科大学附属第一医院眼科, 中国四川省泸州市,646000 |
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| 摘 要： | βB2晶状体蛋白是β族晶状体蛋白中含量最多的一种，在维持晶状体的透明性和屈光性中起着重要作用。βB2晶状体蛋白异常可能与多种类型白内障的形成有关。近年来，CRYBB2基因突变所致白内障的机制成为研究的热点。本文将对βB2晶状体蛋白的结构、功能、相关突变、与各类型白内障关系做一综述。
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| 关 键 词： | βB2晶状体蛋白 白内障 功能 结构 |
| 收稿时间： | 2015/11/5 0:00:00 |
| 修稿时间： | 2016/1/11 0:00:00 |
Beta B2-crystallin and cataract |
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| Yan Jiang,Gang-Jin Kang,Man-Hua Xu and Kai-Ming Li.Beta B2-crystallin and cataract[J].International Journal of Ophthalmology,2016,16(2):261-264. |
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| Authors: | Yan Jiang Gang-Jin Kang Man-Hua Xu and Kai-Ming Li |
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| Institution: | Department of Ophthalmology, the First Affiliated Hospital of Sichuan Medical University, Luzhou 646000, Sichuan Province, China;Department of Ophthalmology, the First Affiliated Hospital of Sichuan Medical University, Luzhou 646000, Sichuan Province, China;Department of Ophthalmology, the First Affiliated Hospital of Sichuan Medical University, Luzhou 646000, Sichuan Province, China;Department of Ophthalmology, the First Affiliated Hospital of Sichuan Medical University, Luzhou 646000, Sichuan Province, China |
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| Abstract: | ?Beta B2-crystallin is the most abundant crystallin in theβ-family, which plays an important role in the maintenance of the lens transparency and refraction.The abnormal of beta B2-crystallin may be associated with the formation of various types of cataract.In recent years, the mechanism of cataract which caused by the related mutations of CRYBB2 gene is becoming a hot spot of research.This article summarized the structure, function and mutation of beta B2-crystallin and its relations with various types of cataract. |
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| Keywords: | beta B2-crystallin cataract function structure |
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