Increased susceptibility to cephamycin-type antibiotics of methicillin-resistant Staphylococcus aureus defective in penicillin-binding protein 2. |
| |
| Authors: | K Murakami K Nomura M Doi T Yoshida |
| |
| Affiliation: | Shionogi Research Laboratories, Shionogi and Co., Ltd., Osaka, Japan. |
| |
| Abstract: | A methicillin-resistant strain of Staphylococcus aureus which produced low-affinity penicillin-binding protein 2' (PBP 2') spontaneously lost PBP 2 when the strain was cultivated at 43 degrees C overnight. At 37 degrees C, the mutant had increased susceptibility to cephamycin-type beta-lactams, which showed high affinity for PBP 4. This result suggests that inhibition of PBP 4, in addition to that of PBP 2, is necessary to kill methicillin-resistant strains. |
| |
| Keywords: | |
|
|
