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| 丰富环境干预对短暂性全脑缺血大鼠海马形态学影响 | |
| 引用本文： | 蔺勇,郎云峰,张扬,程永杰. 丰富环境干预对短暂性全脑缺血大鼠海马形态学影响[J]. 中国实验诊断学, 2011, 15(8): 1252-1253 |
| 作者姓名： | 蔺勇 郎云峰 张扬 程永杰 |
| 作者单位： | 1. 长春市中心医院,神经内科,吉林,长春130051 2. 吉林大学第一医院,吉林,长春130021 3. 吉林大学药学院,生物药学系,吉林,长春130021 |
| 基金项目： | 吉林省卫生厅重点实验室资助项目 |
| 摘 要： | 目的探讨丰富环境干预对短暂性全脑缺血大鼠海马形态学的影响。方法将Wistar大鼠分组建立短暂性全脑缺血模型,进行丰富环境干预,进行大鼠海马形态学分析。结果 HE染色显示,与IS组相比,IE组海马CA1区组织的病理损伤明显减轻。锥体神经元排列较规则,肿胀、固缩及脱失神经元数目较少。Nissl染色显示,IS组海马细胞层数减少,神经元细胞间隙变大,排列稀疏,细胞形态异常,尼氏体大量脱失,染色浅谈且出现较多空白区;IE组海马区仅见少量神经元缺失及胶质增生,但细胞形态基本正常,细胞排列较为整齐,尼氏体较清晰。结论丰富环境干预可以改善脑缺血大鼠海马的病理损伤程度。 |
| 关 键 词： | 丰富环境 可塑性 大鼠 |
The effect of enriched rehabilitative training on the structure of hippocampus in rats after transient global cerebral ischemia |
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| LIN Yong,LIANG Yun-feng,CHENG Yong-jie,et al.. The effect of enriched rehabilitative training on the structure of hippocampus in rats after transient global cerebral ischemia[J]. Chinese Journal of Laboratory Diagnosis, 2011, 15(8): 1252-1253 | |
| Authors: | LIN Yong LIANG Yun-feng CHENG Yong-jie et al. |
| Affiliation: | LIN Yong1,LIANG Yun-feng2,CHENG Yong-jie1,et al.(1.Department of Neurology,Changchun Central Hospital,Changchun 130051,China,2.The First Hospital of Jilin University,Changchun 130021,China) |
| Abstract: | Objective To investigate the effect of enriched rehabilitative training on hippocampus impairment in rats after transient global cerebral ischemia.Methods Adult male Wistar rats were used in the study.Rats were randomly assigned to either enriched environment housing or standard condition.The pathological changes in hippocampal cells were observed with H-E stain and Nissl stain.Results Compared with that in the SS group,the injury of CA1 region of the hippocampus was severe in the IS group.The raritas and d... |
| Keywords: | enriched environment plasticity rats |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |