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Chemical impurities and contaminants in different silicone oils in human eyes before and after prolonged use |
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| Authors: | Simon Brunner Barbara Izay Bernhard Weidinger Beate Maichel Susanne Binder |
| Affiliation: | (1) Department of Ophthalmology, The Rudolph Foundation Hospital, Juchgasse 25, 1030 Vienna, Austria;(2) Ludwig-Boltzmann-Institute for Retinology and Biomicroscopic Laser Surgery, Vienna, Austria;(3) Institute for Medical Statistics and Documentation, University of Vienna, Vienna, Austria;(4) Ofi — Scientific Institute for Chemistry and Technics, Vienna, Austria;(5) Croma-Pharma GmbH, Korneuburg, Austria |
| Abstract: | BackgroundIntraocular silicone oil (SiO) impurities as low molecular weight components (LMWC) and residual catalysts are thought to cause ocular toxicity. A case-control study was initiated to determine if highly purified SiOs of equal viscosity from two different manufacturers had a similar chemical stability after prolonged clinical use as a vitreous substitute in patients. |
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