|
|||||
|
|
| NO-1886降低脂负荷新西兰兔血清甘油三酯和游离脂肪酸 | |
| 引用本文： | 张弛,肖俊霞,席守民,张秋菊,王宗保,Kusunoki M,Tsutsumi K,尹卫东.NO-1886降低脂负荷新西兰兔血清甘油三酯和游离脂肪酸[J].中国药理学通报,2005,21(3):280-283. |
| 作者姓名： | 张弛 肖俊霞 席守民 张秋菊 王宗保 Kusunoki M Tsutsumi K 尹卫东 |
| 作者单位： | 1. 南华大学生物化学与分子生物学教研室,湖南,衡阳,421001 2. 南华大学肿瘤研究所,湖南,衡阳,421001 3. 南华大学实验动物学部,湖南,衡阳,421001 4. Dept of Internal Medicine,Faculty of Medicine, Aichi Medical University,Nagakute-cho, Aichigunte, Aichi 480-11, Japan 5. Research and Development, Otsuka Pharmaceutical Factory Inc,Tokushima,Japan 6. 南华大学生物化学与分子生物学教研室,湖南,衡阳,421001;南华大学心血管病研究所,湖南,衡阳,421001 |
| 基金项目： | 国家重点基础研究发展计划(973计划)，国家自然科学基金，日本大塚制药厂新药研究项目 |
| 摘 要： | 目的观察NO1886(ibrolipim)对脂肪餐后血脂水平的影响。方法将25只♂新西兰兔随机分为5组正常对照组、脂负荷组、脂负荷+NO1886(05g·kg-1)组、脂负荷+NO1886(10g·kg-1)组、脂负荷+NO1886(15g·kg-1)组;分别在给予20%脂肪乳和相应剂量NO1886前后第1、2、4、6、8、24h从兔耳缘静脉采血,离心收集血清,测定血清甘油三酯和游离脂肪酸。结果NO1886能有效地降低脂负荷后新西兰兔血清甘油三酯和游离脂肪酸水平,呈剂量依赖性,并能使游离脂肪酸恢复到正常。结论NO1886具有调节脂肪餐后血脂水平的作用。 |
| 关 键 词： | 甘油三脂 游离脂肪酸 脂肪耐量实验 新西兰兔 NO-1886 |
| 文章编号： | 1001-1978(2005)03-0280-04 |
| 修稿时间： | 2004年7月7日 |
NO-1886 decreases postprandial triglyceride and free fatty acids in New Zealand rabbits |
|
| ZHANG Chi,XIAO Jun-xia,XI Shou-min,ZHANG Qiu-ju,WANG Zong-bao,Kusunoki M,Tsutsumi K,YIN Wei-dong.NO-1886 decreases postprandial triglyceride and free fatty acids in New Zealand rabbits[J].Chinese Pharmacological Bulletin,2005,21(3):280-283. | |
| Authors: | ZHANG Chi XIAO Jun-xia XI Shou-min ZHANG Qiu-ju WANG Zong-bao Kusunoki M Tsutsumi K YIN Wei-dong |
| Abstract: | Aim To ascertain the effect of NO-1886 on postprandial hyperlipidemia in New Zealand rabbits.Methods Twenty-five male rabbits were randomized into five groups (n=5 in normal control group; n=5 in fat-meal group; n=5 in fat-meal supplemented with 0.5 g·kg~-1 body weight NO-1886 group;n=5 in fat-meal supplemented with 1.0 g·kg~-1 body weight NO-1886 group;n=5 in fat-meal supplemented with 1.5 g·kg~-1 body weight NO-1886 group ). Blood samples were withdrawn from the vein of auricle of the animals before administration of the fat-meal and NO-1886 and at 1,2,4,6,8,24 hr after the meal and the drug. Postprandial serum TG and FFA levels were determined. Results NO-1886 reduced postprandial serum TG and FFA levels of New Zealand rabbits during the fat-tolerance test in dose-dependent manner. Conclusion NO-1886 has a role in regulating postprandial blood lipids,it is worthwhile to conduct further study in this aspect. |
| Keywords: | NO-1886 |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |