Moesin和E-cadherin与甲状腺乳头状癌侵袭的相关性

目的探讨膜突蛋白（Moesin）和上皮型钙黏蛋白（E-cadherin）在甲状腺乳头状癌侵袭、转移中的作用。方法采用免疫组织化学SP法，检测81例甲状腺乳头状癌和癌旁正常组织中Moesin和E-cadherin的表达，并将检测结果结合患者的临床资料(性别、年龄、肿瘤大小、局部侵犯、颈淋巴转移、TNM分期)等进行分析。结果甲状腺乳头状癌中的Moesin和E-cadherin的阳性表达率与癌旁正常甲状腺组织之间的差异均有统计学意义(P<0.01)。患者年龄≥45岁、肿瘤侵犯甲状腺被膜外、有颈淋巴结转移、Ⅲ～Ⅳ期甲状腺乳头状癌， Moesin的阳性表达率增高，差异有统计学意义(P<0.01)；而E-cadherin的阳性表达率降低，差异有统计学意义(P<0.01)。甲状腺乳头状癌中Moesin与E-cadherin的阳性表达具有相关性(r=-0.494，P<0.01)。结论甲状腺乳头状癌中Moesin的高表达和E-cadherin的低表达与肿瘤的侵袭和转移有关，两者之间具有协同作用。

Correlation of Moesin and E-cadherin with Invasion of Papillary Thyroid Carcinoma

Objective To assess the significance of Moesin and E-cadherin in invasion and metastasis of papillary thyroid carcinoma(PTC).Methods The expressions of Moesin and E-cadherin in 81 cases of PTC and normal thyroid tissues adjacent to cancer were analyzed by immunohistochemical staining.The correlation between these 2 factors(Moesin,E-cadherin)and clinical features of PTC such as gender,age,tumor size,invasion and lymph node metastasis were studied.Results The rates of immuno-positive staining of Moesin and E-cadherin in PTC were significantly higher than that in the normal thyroid tissues adjacent to cancer(P<0.01).The positive expression rates of Moesin in PTC with age≥45 years,local invasion,lymph node metastasis and in stage Ⅲ~Ⅳ was higher than PTC with age<45 years,without local invasion,without metastasis and in stage Ⅰ~Ⅱ.There was significant difference,respectively(P<0.01).The positive expression rates of E-cadherin in PTC with age≥45 years,local invasion,lymph node metastasis and in stage Ⅲ~Ⅳ was lower than PTC with age <45 years,without local invasion,without metastasis and in stage Ⅰ~Ⅱ.There was significant difference,respectively(P<0.01).There was correlation between the expressions of Moesin and E-cadherin in PTC(r =-0.494,P<0.01).Conclusion The high expressions of Moesin and the low expression of E-cadherin were related to invasion and metastasis of PTC.And the 2 factors have cooperative.