Efficacy of low-dose cyproterone acetate compared with minocycline in the treatment of acne vulgaris |
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| Authors: | B.E. MONK,J.A. ALMEYDA,I.W. CALDWELL&dagger ,B. GREEN&Dagger ,D. PELTA§ ,J. LEONARD¶ ,A. DU,VIVIER ,K. JOHNSON,I. TOLOWINSKA |
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| Affiliation: | Department of Dermatology, King's College Hospital, London;Chase Farm Hospital, Enfield, Middlesex, London;St Helier General Hospital, Jersey, Channel Islands, London;St Helier General Hospital, Leyton, London;Community Health Centre, Southend-on-Sea, Essex, London;Department of Dermatology, St Mary's Hospital, London;Department of Sihering Health Care Ltd, West Sussex, UK |
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| Abstract: | ![]()
A multi-centre controlled trial of low-dose cyproterone acetate (Diane®, Schering Health t are Ltd) compared with minocycline hydrochloride (Minocin®, Lederle Laboratories Ltd) in female patients with acne vulgaris has been undertaken. Seventy-eight patients completed the study. Over a 24-week treatment period, Diane and Minocin were found to be equally effective in reducing the lesion count for comedones, papules and pustules, and in the patients' subjective assessment of their skin. No significant changes in weight or blood pressure were found in either treatment group, and the number of patients reporting; side-effects was similar. |
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