3种非典型抗精神病药对精神分裂症患者心电图的影响

目的:探讨3种非典型抗精神病药对精神分裂症患者心电图的影响。:方法:将270例精神分裂症患者随机分成3组,分别给予利培酮、阿立哌唑和齐拉西酮治疗,于治疗前和治疗2、4、8周进行心电图检查。结果:利培酮组、阿立哌唑组和齐拉西酮组的心电图异常率分别为27.8%、26.7%和22.2%。其中利培酮组与阿立派唑组女性异常率显著高于男性(P<0.05)。心电图改变主要为T波改变、窦性心动过速、窦性心动过缓、室性期前收缩、不完全右束支传导阻滞。结论:3种非典型抗精神病药对精神分裂症患者心电图均有影响,但轻而可逆。

Comparative study on the electrocardiograph effect of three atypical antipsychotics in schizophrenic patients

Objective:To study the influence of three atypical antipsychotics on electrocardiograph in the treatment of schizophrenic patients.Method:270 schizophrenic inpatients were assigned to one of three groups which received risperidone,aripiprazole or ziprasidone treatment respectively.electrocardiograph was conducted at baseline and week 2,4 and 8.Results:The abnormal electrocardiograph rate of risperidone,aripiprazole and ziprasidone group was 27.8%,26.7% and 22.2%,respectively,The prevalence of abnormal elect...