多西紫杉醇联合氟尿嘧啶及顺铂治疗晚期胃癌

 目的 观察国产多西紫杉醇（TAT）联合亚叶酸钙／5-氟尿嘧啶（CF／5Fu）及顺铂（DDP）治疗晚期胃癌的临床疗效与不良反应。方法 41例晚期胃癌患者接受TAT与CF／5-Fu及DDP联合化疗：TAT75mg／m2，静滴1h，d1；CF100mg，静滴2h，d1-5；5-Fu500mg／m2，22h微泵持续静滴，d1-5；DDP25mg／m2，静滴，d，1-3。28天为一个周期。治疗2个周期后评价疗效和不良反应。结果 41例患者均可评价疗效。完全缓解2例，部分缓解23例，有效率61．0％。中位疾病进展时间7．5个月，中位生存期10．6个月，1年生存率41．5％。主要不良反应为骨髓抑制，脱发和周围神经炎。结论 国产多西紫杉醇联合亚叶酸钙／5-氟尿嘧啶及顺铂治疗晚期胃癌缓解率高，毒副反应可以耐受。

Docetaxel in Combination with 5-Fluorouracil and Cisplatin for Advanced Gastric Cancer

Objective 　To evaluate the efficacy and toxicity of domestic Docetaxel in combination with Calcium Folinate/ 5-Fluorouracil and Cisplatin on advanced gastric cancer. Methods 　Forty-one patients with advanced gastric cancer were treated by Docetaxel 75 2/7 on d1 , Calcium Folinate 100mg on d1～5 , 5-Fluorouracil 00mg/ m² on d1～5 , Cisplatin 25mg/ m² on d1～3 , with 28 days one cycle. The efficacy and adverse effect were evaluated after two cycles. Results 　Forty-one patients can be included for response rate. 2 showed complete response and 23 partial responses with an overall response rate of 61. 0 %(25/ 41) . Median time to progression was 7. 5 months , and 12year survival rates was 41. 5 % with median survival time of 10. 6 months. The main dverse effect was myelosuppression , alopecia and peripheral neuritis. Conclusion 　The regimen of domestic Docetaxel combined with Calcium Folinate/ 5-Fluorouracil and Cisplatin for patients with advanced gastric cancer produced high response rate and its toxicity is well tolerable.