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| BRAF基因突变与皮肤恶性黑素瘤 | |
| 引用本文： | 郑博文,何黎,张林,邹勇莉. BRAF基因突变与皮肤恶性黑素瘤[J]. 国际皮肤性病学杂志, 2009, 35(4). DOI: 10.3760/cma.j.issn.1673-4173.2009.04.022 |
| 作者姓名： | 郑博文 何黎 张林 邹勇莉 |
| 作者单位： | 1. 昆明医学院第一附属医院皮肤科,650032 2. 昆明医学院第一附属医院病理科,650032 |
| 摘 要： | BRAF基因,位于染色体7q34编码一个67 000～99 000的丝,苏氨酸蛋白激酶,其产物在丝裂原活化蛋白激酶信号途径中起重要调控作用.国内外的研究者先后发现并揭示出BRAF基因变异与皮肤恶性黑素瘤的关系.随着探索的深入,部分学者以BRAF基因作为治疗靶向进行研究,并初步取得成果.对BRAF基因及其突变的研究可能在未来恶性黑素瘤诊断、治疗以及预后等方面产生临床价值,为恶性黑素瘤的治疗开辟新的方向. |
| 关 键 词： | 黑色素瘤 基因,BRAF 突变 |
BRAF gene mutation and cutaneous melanoma |
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| ZHENG Bo-wen,HE Li,ZHANG Lin,ZOU Yong-li. BRAF gene mutation and cutaneous melanoma[J]. International Journal of Dermatology and Venereology, 2009, 35(4). DOI: 10.3760/cma.j.issn.1673-4173.2009.04.022 | |
| Authors: | ZHENG Bo-wen HE Li ZHANG Lin ZOU Yong-li |
| Abstract: | BRAF gene, located in chromosome 7q34, encodes a serine/threonine protein kinase of 67-99 kilodalton which plays an important regulating role in the pathway of mitogen-activated protein kinase (MAPK). Recent studies have revealed the relationship between BRAF gene mutation and cutaneous melanoma. Some progress has been made in the research about BRAF gene-targeting therapy. To study BRAF gene and its mutation may benefit the diagnosis, treatment and prognosis evaluation of melanoma. |
| Keywords: | Melanoma Gene,BRAF Mutation |
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