Class II (DR) antigen expression on CD8+ lymphocyte subsets in acquired immune deficiency syndrome (AIDS) |
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Authors: | H W L Ziegler-Heitbrock D Stachel T Schlunk L Gürtler W Schramm M Fröschl J R Bogner G Riethmüller |
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Institution: | (1) Institute for Immunology, University of Munich, 8000 Munich, FRG;(2) Genzentrum, University of Munich, 8000 Munich, FRG;(3) Max-von-Pettenkofer-Institute, University of Munich, 8000 Munich, FRG;(4) Hemostasiology Laboratory Department of Internal Medicine, University of Munich, 8000 Munich, FRG;(5) Department of Dermatology, University of Munich, 8000 Munich, FRG;(6) Medizinische Poliklinik, University of Munich, 8000 Munich, FRG;(7) Institute for Immunology, Goethestr. 31, 8000 Munich 2, FRG |
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Abstract: | In a selected group of human immunodeficiency virus (HIV)-infected patients we confirm the expansion of a CD8+ T-lymphocyte subset, i.e., the CD8+/Leu7+ cells, which account for 30% of the lymphocytes, compared to 3% in the control donors. In addition, a CD8+ T-lymphocyte subset that coexpresses class II (DR) antigens, i.e., CD8+/DR+ cells, is also increased from 1.5% in controls to 27% in the HIV-infected patients. Using three-color immunofluorescence and flow cytometry we can demonstrate that the CD8+/Leu7+ and the CD8+/class II+ cells are not distinct but overlapping subsets. In the HIV-infected patients 42% of the CD8+/Leu7+ cells were strongly positive for class II and these CD8+/Leu7+/class II+ cells accounted for 13% of all lymphocytes. These findings indicate that the expanded CD8+/Leu7+ cells are activated and hence might be actively involved in immune defense in acquired immune deficiency syndrome (AIDS). |
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Keywords: | Acquired immune deficiency syndrome (AIDS) T8 cells three-color immunofluorescence flow cytometry |
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