常见太白七药的安全性研究现状及思路

太白七药是太白山特有的珍贵药材,太白七药有149种,涉及地衣、苔藓、蕨类及种子植物四大门类,多具有活血化瘀、抗炎镇痛、祛风湿和抗肿瘤等功效,临床应用广泛。但在长期的应用中,部分七药显示出毒性作用,其中毛茛科乌头属和小檗科的部分七药毒性机制被研究的较多,而其他科属七药的毒性研究相对较少,因此对有毒七药进行安全性评价至关重要。关于对太白七药的安全性研究,参照现代药理学方法和中药新药研究规范,通过急性毒性实验、长期毒性实验、全身毒性试验以及特殊毒性试验,采取新技术和新方法从整体动物、靶组织、细胞及分子水平探讨七药的毒性作用机制,确定毒性药物的中毒剂量、时间及靶器官、靶点等参数,为临床和新药开发奠定基础。

The Development of the Safety Study on the Common Taibai Qiyao

Taibai Qiyao were endemic and precious herbs in Taibai Mountains. There were 149 herbs,such as lichens,mosses,ferns and seed plants in four major categories,with the function of promoting blood circulation and removing stasis,anti-inflammation,analgesic effect,removing wind-dampnessrheumatism and anti-tumor,and were applied in clinic widely. However,some herbs of Taibai Qiyao exhibit toxicity in the long-term use. There were a lot of studies on the toxicity mechanisms of Ranunculaceae aconitum and Berberidaceae,but few studies on other herbs. So it is very important to evaluate the safety of the toxic Taibai Qiyao. In view of the safety study of Taibai Qiyao,according to the modern pharmacological methods and traditional Chinese medicine research standards,through acute toxicity test,long-term toxicity test,systemic toxicity test and special toxicity test,new technology and new methods were applied on the levels of the whole animal,cell and molecule to explore the toxic mechanism of Taibai Qiyao to determine the toxic drug dose,time and target organs,targets and other parameters,and therefore to lay a foundation for the clinical and new drug development.