蓝芩口服液联合头孢克肟治疗小儿急性咽炎的临床研究

目的探讨蓝芩口服液联合头孢克肟治疗小儿急性咽炎临床疗效。方法选取2018年1月—2020年1月在河南大学第一附属医院治疗的92例急性咽炎患儿,随机分为对照组和治疗组,每组各46例。对照组患者口服头孢克肟颗粒,1.5~3.0 mg/kg,2次/d。治疗组在对照组的基础上口服蓝芩口服液,20 mL/次,3次/d。两组患者均连续治疗7 d。观察两组患者临床疗效,同时比较治疗前后两组患者临床症状消失时间、血清炎性因子水平和不良反应。结果治疗后,对照组和治疗组临床有效率分别为78.26%和95.65%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患儿咽部红肿、咽痛、咳痰症状消失时间均早于对照组(P<0.05)。治疗后,两组患儿血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平均明显降低(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗期间,对照组不良反应发生率为23.91%,显著高于治疗组的10.87%,两组比较差异具有统计学意义(P<0.05)。结论蓝芩口服液联合头孢克肟治疗小儿急性咽炎的临床疗效显著,能明显改善患儿临床症状消失时间,有效改善血清炎性因子水平,具有一定的临床推广应用价值。

Clinical study on Lanqin Oral Liquid combined with cefixime in treatment of acute pharyngitis in children

Objective To explore the curative effect of Lanqin Oral Liquid combined with cefixime in treatment of acute pharyngitis in children. Methods Children(92 cases) with acute pharyngitis in the First Affiliated Hospital of Henan University from January 2018 to January 2020 were randomly divided into control and treatment groups, and each group had 46 cases. Children in the control group were po administered with Cefixime Granules, 1.5 — 3.0 mg/kg, twice daily. Children in the treatment group were po administered with Lanqin Oral Liquid on the basis of the control group, 20 mL/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the recovery time of clinical symptoms, the levels of serum inflammatory factors and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 78.26% and 95.65%, respectively, and there were differences between two groups(P < 0.05). After treatment, the disappearance time of swollen pharynx, sore throat and expectoration in the treatment group was significantly earlier than that in the control group(P < 0.05). After treatment, the serum levels of IL-6, TNF-α, and CRP in two groups were significantly decreased(P < 0.05), and the levels of serum inflammatory factors in the treatment group were significantly lower than those in the control group(P < 0.05). During the treatment, the adverse reactions rate in the control group was 23.91%, which was significantly higher than 10.87% in treatment the group, with significant difference between two groups(P < 0.05). Conclusion Lanqin Oral Liquid combined with cefixime has a significant clinical effect in treatment of acute pharyngitis in children, can significantly improve the recovery time and effectively improve the level of serum inflammatory factors, which has a certain clinical application value.