各型急性脑梗死患者超敏C-反应蛋白水平及相关因素分析

目的探讨不同TOAST病因学分型急性脑梗死（ACI）患者血清超敏C-反应蛋白（hs-CRP）水平及相关因素的关系。方法ACI住院患者116例,在发病72h之内测定血清hs-CRP的水平及其他生化指标,应用TOAST病因分型分类后,各亚型与30例健康对照者进行对比。结果除其他明确病因型（SOE）因病例少未作分析,其他ACI各亚型血清hs-CRP水平明显高于对照组（P〈0.05）,其中大动脉粥样硬化（LAA）型血清hs-CRP水平增高最显著,明显高于其他亚型;心源性栓塞（CE）型血清hs-CRP水平明显高于小动脉闭塞（SAO）型和不明原因（SUE）型。hs-CRP分别与收缩压（SBP,r=0.322,P=0.022）、总胆固醇（TC,r=0.322,P=0.021）、低密度脂蛋白-胆固醇（LDL-C,r=0.358,P=0.011）、糖化血红蛋白（HbA1c,r=0.271,P=0.032）、纤维蛋白原（Fbg,r=0.289,P=0.029）、同型半胱氨酸（Hcy,r=0.301,P=0.023）呈正相关。结论血清hs-CRP水平在不同亚型的ACI明显不同,hs-CRP水平与动脉粥样硬化的发生有一定相关性。

Analysis of levels of serum high sensitivity C-reactive protein and its correlation factors in acute cerebral infarction patients

Objective To investigate the correlation of levels of serum high sensitivity C-reactive protein（hs-CRP） with different stroke subtypes of acute cerebral infarction（ACI）.Methods The serum hs-CRP levels and some biochemical parameters were measured within 72 h after the onset in 116 ACI patients.All ACI patients were classified into 5 stroke subtypes based on TOAST criteria and 30 healthy ones were as control group.The stroke subtype in both groups were compared.Results The levels of serum hs-CRP in stroke subtypes of ACI patients were higher than that of control group（P0.05）except a few ascertained ecological types that were too less in number to analyze.The level of serum hs-CRP in large-artery atherosclerosis（LAA） was the highest.The level of serum hs-CRP in cardioembolism（CE）was higher than that of small-artery occlusion Lacunar（SAO）and other undemonstrated etiology（SUE）.The level of serum hs-CRP was positively correlated with systolic blood pressure（SBP,r=0.322 P=0.022）,total cholesterol（TC）（r=0.322 P=0.021）,low density lipoprotein-cholesterol（LDL-C）（r=0.358 P=0.011）,glycosylated hemoglobin（HbA1c）（r=0.271 P=0.032）,fibrinogen（Fbg）（r=0.289 P=0.029）and homocysteine（Hcy）（r=0.301 P=0.023）.Conclusions The level of serum hs-CRP varies with different subtypes of ACI.The level of serum hs-CRP is correlated with atherosclerosis.