高迁移率族蛋白B1-Toll样受体途径与炎症性肠病

高迁移率族蛋白B1(HMGB1)广泛存在于体内各种细胞中,在组织损伤时由坏死细胞被动释放或由免疫细胞受病原体产物刺激后主动释放至胞外,发挥促炎细胞因子作用,参与多种炎症性疾病的发生、发展和转归。Toll样受体(TLRs)是HMGB1的主要受体之一,HMGB1与TLR2、TLR4相互作用,最终激活NF-κB,导致大量炎症因子释放,通过正反馈作用放大炎症反应。近年研究表明HMGB1-TLR途径与炎症性肠病的发生、发展有关,本文就两者间的关系作一综述。

High Mobility Group Box 1-Toll-like Receptors Pathway in Inflammatory Bowel Disease

High mobility group box 1 （HMGB1） is widely present in various somatic cells. It could be passively or actively released into the extracellular milieu by necrotic cells from damaged tissue or by immune cells stimulated by pathogen products, functioning as a proinflammatory cytokine, triggering and contributing to the progression and turnover of diverse inflammatory diseases. Toll-like receptors （TLRs） are the main receptors for HMGB1. HMGB1 can induce NF-KB activation via interaction with TLR2 and TLR4, which resulted in secretion of a large amount of inflammatory cytokines and a positive feedback to promote expansion of inflammation. Recent studies suggested a correlation between HMGB1-TLRs pathway and the pathogenesis and development of inflammatory bowel disease （IBD）. This article reviewed the relation between HMGB1-TLRs pathway and IBD.