肝硬化患者幽门螺杆菌感染与血清肌钙蛋白T的关系

目的：探讨肝硬化患者幽门螺杆菌（HP）感染与血清肌钙蛋白T（cTNT）的关系。方法：乙肝后硬化患者140例,经检测HP后分HP阴性和阳性组,并设正常对照组,分别测定各组的cTNT;对于HP阳性病例根治HP后再次测定cTNT,并与根治前进行比较;同时,将HP阳性病例分为大量感染组、中量感染组及少量感染组,分别比较各组的cTNT;另外,对于HP阴性和阳性组病例,根据肝功能Child分级进行分组,分别比较各组的cTNT。结果：HP阳性组cTNT明显高于HP阴性组和对照组（P＜0．01）,HP阴性组明显高于对照组（P＜0．05）,HP根治后cTNT显著下降（P＜0．01）;大量感染组明显高于中量及少量感染组（P＜0．01－0．05）;中量感染组亦明显高于少量感染组（P＜0．01）;HP阳性组中肝功能Child C、B级组明显高于A级组（P＜0．01）C级组又明显高于B级组（P＜0．05）,而HP阴性组中各组之间差异无显著意义（P＞0．05）。结论：HP感染使肝硬化患者血cTNT升高,易于并发心肌损害,根治HP有利于防治该并发症。

Relationship between Helicobacter pylori infection and serum level of cTNT in patients with cirrhosis

Objective To explore the relationship between Helicobacter pylori (HP) infection and the serum level of cTNT in patients with cirrhosis. Methods 140 patients with cirrhosis after chronic hepatitis B were divided into HP infected group (HP group) and HP uninfected group (nHP group). A normal group of healthy people was set up as control. Then, the HP group was further divided into mild (mHP), medium (dHP), and severe (sHP) subgroups according to the severity degree of HP infection. And all the 140 cirrhosis patients were redivided into different grade groups (subgroups A, B, C) according to child's system. The blood cTNT levels of each group were determined. In HP group, the blood cTNT level was re-determined after the wholly treatment of HP. Results The cTNT level in HP group was significantly higher than those of nHP group and control group. In nHP group it was significantly higher than that of control group andit decreased markedly after the wholly treatment of HP. The cTNT level of mHp subgroup was significantly higher than those of dHP and sHP subgroup. In dHP subgroup it was significantly higher than that of sHP subgroup. In HP group, the cTNT levels in subgroups B and C were significantly higher than infection subgroups A, and in subgroup C was significantly higher than infection subgroup B. There was no significant difference among uninfected group. Conclusion Hp infected could increase the blood cTNT level of cirrhosis patients and make it easier for these patients to be attacked by myocardium damaged. Curing HP is advantageons to the preventiong and curing myocardium damaged.