脑膜瘤围手术期应用盐酸右美托咪定对血清NSE及IL-6的影响

目的:观察脑膜瘤围手术期应用盐酸右美托咪定对血清神经元特异性烯醇化酶(NSE)及白介素-6(IL-6)的影响.方法:64例接受手术治疗的脑膜瘤患者随机分为观察组和对照组,每组各32例.观察组在围术期应用盐酸右美托咪定,对照组使用同量的生理盐水.比较2组在T1、T2、T3、T4时点NSE、IL-6水平变化以及T1、T2、...

Effect of Dexmedetomidine Hydrochloride on Serum NSE and IL-6 of Meningioma During Perioperative Period

[Objective]Todetermine whether the application of dexmedetomidine during the perioperative period of meningioma mediate the NSE and interleukin IL-6 level in serum.[Method]Total 64 patients diagnosed with meningiomas were randomly divided into two groups(observation group and control group)with 32 cases in each.Dexmedetomidine hydrochloride was appliedwithin the perioperative period in the observation group,while in controlgroup the same volume of saline was used.Plasma was collected at T1,T2,T3 and T4,and the protein level of NSE and IL-6 were assessed.The alteration of CaO₂,Da-jvO₂,CEO₂ and the side effects were recorded at the time points of T1,T2 and T3.[Result]At T2,T3 and T4 time points,protein concentrations in the serum(NSE and IL-6)were significantly lower when dexmedetomidine was administered(P<0.05).The levels of Da-jvO₂ and CEO₂ were profoundly downregulated by dexmedetomidine at T2 and T3 time points(P<0.05).[Conclusion]The effectiveness of dexmedetomidine hydrochloride used in the perioperative period among meningioma patients was established by the prevention of the increase of NSE and IL-6 levels and the up-regulation of cerebral oxygen metabolism.It may extend the current clinical application range of dexmedetomidine not only acting as a perioperative and procedural sedative agent but also playing a critical role in the regulation of neural oxidative stress response.