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| 结直肠癌同时性肝转移患者原发灶切除的预后分析 | |
| 引用本文： | 马晓龙,关旭,杨润坤,刘恩瑞,魏然,赵志勋,黄海洋,陈海鹏,刘正,姜争,陈瑛罡,王锡山. 结直肠癌同时性肝转移患者原发灶切除的预后分析[J]. 中华结直肠疾病电子杂志, 2021, 0(1): 50-55 |
| 作者姓名： | 马晓龙 关旭 杨润坤 刘恩瑞 魏然 赵志勋 黄海洋 陈海鹏 刘正 姜争 陈瑛罡 王锡山 |
| 作者单位： | 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院结直肠外科;哈尔滨医科大学附属第二医院结直肠肿瘤外科;国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院深圳医院胃肠外科 |
| 基金项目： | 深圳市‘医疗卫生三名工程’(No.SZSM201911012);中国医学科学院医学与健康科技创新工程项目(No.2016-I2M-1-001);北京市科技计划(No.D171100002617002,No.D171100002617004);中国癌症基金会,北京希望马拉松专项基金青年课题(No.LC2019B14)。 |
| 摘 要： | 目的 原发灶切除能否使结直肠癌肝转移患者生存获益,目前仍有争议.本研究探讨接受原发灶切除结直肠癌肝转移患者的生存状况及预后的影响因素.方法 回顾性分析2010年1月～2018年2月在国家癌症中心/中国医学科学院肿瘤医院治疗的371例结直肠癌同时性肝转移患者的病例资料.根据治疗方式分为单纯化疗组和原发灶切除组,分析两组患... |
| 关 键 词： | 结直肠肿瘤 肝转移 原发灶切除 化疗 预后 |
Palliative primary tumor resection provides survival benefits for the patients with synchronous liver metastases colorectal cancer |
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| Ma Xiaolong,Guan Xu,Yang Runkun,Liu Enrui,Wei Ran,Zhao Zhixun,Huang Haiyang,Chen Haipeng,Liu Zheng,Jiang Zheng,Chen Yinggang,Wang Xishan. Palliative primary tumor resection provides survival benefits for the patients with synchronous liver metastases colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2021, 0(1): 50-55 | |
| Authors: | Ma Xiaolong Guan Xu Yang Runkun Liu Enrui Wei Ran Zhao Zhixun Huang Haiyang Chen Haipeng Liu Zheng Jiang Zheng Chen Yinggang Wang Xishan |
| Affiliation: | (Department of Colorectal Surgery,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Department of Colorectal Surgery,The Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China;Department of Gastrointestinal Surgery,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen 518116,China) |
| Abstract: | Objective It is still under debate that whether unresectable liver metastases colorectal cancer patients can benefit from primary tumor resection.We aim to evaluate the survival benefits and prognostic factors of patients undergoing primary tumor resection.Methods A retrospective analysis of 371 patients with synchronous liver metastases of colorectal cancer diagnosed and treated at the National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College from January 2010 to February 2018.According to the treatment methods,the patients were divided into chemotherapy group and primary tumor resection group.The prognosis of the two groups was analyzed and compared.Two groups were matched by the propensity score matching method,and Kaplan-Meier method was used to draw the survival curve,Log rank test was used to analyze the survival difference of two groups.Cox proportional risk model was used to analyze the factors affecting the prognosis of patients with unresectable synchronous liver metastases.Results A total of 371 patients were included in this study,which 209 patients received chemotherapy and 162 patients received primary tumor resection.After propensity score matching,288 patients were included for statistical analysis.The prognosis of the primary tumor resection group was better than the chemotherapy group(median survival time 22 months vs.16 months,and the 3-year CSS was 21.4%vs.10.2%)(χ2=20.37,P<0.01).Multivariate analysis found that unresected primary tumor,right colon cancer,mucinous adenocarcinoma,lymph node metastasis and CEA abnormality were independent risk factors.Subgroup analysis showed that the patients could benefit from resection of the primary tumor except for patients with right colon cancer and negative lymph node.Conclusion For colorectal cancer patients with unresectable liver metastases,resection of the primary tumor can improve the cancer-specific survival. |
| Keywords: | Colorectal neoplasms Liver metastases Primary tumor resection Chemotherapy Prognosis |
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