10772例患者抗核抗体谱检测结果的回顾性分析

目的 探讨抗核抗体(ANA)谱检测结果及筛查的意义.方法 用免疫印迹法对10772例患者进行ANA谱检测,并对结果进行回顾性分析.结果 10772例患者中,ANA谱阳性2671例,阳性率为24.8％.女性患者阳性率为27.7％,高于男性患者的21.0％(P<0.05).总体ANA谱检测阳性率最高的前5项依次是抗Ro-5...

Retrospective analysis of the detection results of anti-nuclear antibody spectrum in 10772 patients

Objective To explore the detection results and significance of screening of anti-nuclear antibody(ANA)spectrum.Methods The ANA spectrum of 10772 patients was detected by Western blotting method,and the results were analyzed retrospectively.Results Among the 10772 patients,2671 cases were ANA spectrum positive,the positive rate was 24.8%.The positive rate of female patients was 27.7%,which was higher than 21.0%of male patients(P<0.05).The top 5 items with the highest positive rate of the overall ANA spectrum test were anti-Ro-52 antibody(6.9%),anti-SSA antibody(4.6%),anti-AMA-M2 antibody(3.6%),anti-histone antibody(2.6%),and anti-dsDNA antibody(2.2%);the top 5 items with the highest positive rate in male patients were anti-Ro-52 antibody(5.0%),anti-AMA-M2 antibody(3.2%),anti-SSA antibody(2.7%),anti-histone antibody(2.2%),anti-PM-Scl antibody(2.0%);the top 5 items with the highest positive rate in female patients were anti-Ro-52 antibody(8.4%),anti-SSA antibody(6.1%),anti-AMA-M2 antibody(4.0%),anti-histone antibody(3.0%),anti-CENP-B antibody(2.9%).Conclusion There is a certain positive rate of ANA spectrum,and there are differences in the gender of the tested population.ANA spectrum screening should be carried out during clinical diagnosis and treatment to prevent missed diagnosis of autoimmune disease(AID).