139例儿童鼠伤寒沙门菌肠炎的临床特点及耐药性分析

目的 通过分析鼠伤寒沙门菌肠炎的临床特点以及耐药情况,指导本地区鼠伤寒沙门菌肠炎合理使用抗生素.方法 回顾性分析2016年1月—2019年12月河源市妇幼保健院收治139例鼠伤寒沙门菌肠炎患儿的临床特点及耐药情况.结果 发病高峰期为每年5—10月份.139例鼠伤寒沙门菌肠炎患儿中,2016年发病34例,2017年发病3...

Clinical Characteristics and Drug Resistance Salmonella Typhimurium Enteritis in 139 Children

Objective By analyzing the clinical characteristics and drug resistance of Salmonella typhimurium enteritis,it is instructed to use antibiotics in this area.Methods The clinical characteristics and drug resistance of 139 children with Salmonella typhimurium enteritis admitted to Heyuan Maternal and Child Health Hospital from January 2016 to December 2019 were retrospectively analyzed.Results The peak period of onset is from May to October every year.Among the 139 children with Salmonella Typhimurium enteritis,34 cases occurred in 2016,35 cases occurred in 2017,42 cases in 2018,and 29 cases in 2019.There were 109 cases(78.42%)under 2 years of age,which was the main age of onset.Among the 139 children,86 were male and 53 were female.The ratio of male to female was 1.48:1.The minimum age is 7 days,the maximum age is 7 years,and the middle age is 1.14(0.67,1.81)years.Diarrhea and fever are the main clinical manifestations.All children have increased stool frequency and change in stool characteristics.63 cases(45.32%)of watery stools with mucus bloodshot eyes and 130 cases(93.53%)of fever.Can be combined with other system diseases.Laboratory tests showed that 128 cases(92.09%)of red blood cells,133 cases(95.68%)of white blood cells,and 48 cases(34.53%)of pus cells were found in stool.118 cases(84.89%)with reactive protein>8 mg/L;82 cases(58.99%)with serum procalcitonin>0.5 ng/L.Drug susceptibility suggests that there are no drug-resistant strains of carbapenems(meropenem,imipenem)and quinolones(ciprofloxacin,levofloxacin),and theβ-lactamase inhibitor mixture is highly sensitive.The third-generation cephalosporins have different degrees of resistance,and the resistance rates of ampicillin,piperacillin and cefuroxime axetil are higher.In 4 years,there were 27 multi-drug resistant strains.Conclusion Salmonella typhimurium enteritis is common in infants and children under 2 years of age,and the high incidence season is in summer and autumn.Diarrhea and fever are the main clinical manifestations.Salmonella typhimurium in this area has drug-resistant strains and multi-drug resistant bacteria.The antibiotics should be selected according to the results of drug sensitivity and the use of antibiotics in the course of foot treatment to minimize the production of drug-resistant strains.