Naloxone administration following operant training of sucrose/water discrimination in the rat |
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Authors: | E O’Hare J Cleary D T Weldon C J Billington A S Levine P J Bartz |
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Institution: | (1) GRECC (11G), Veterans Affairs Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA, US;(2) Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA, US;(3) Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA, US;(4) School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA, US;(5) School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA, US;(6) Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA, US |
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Abstract: | The suppression of food intake observed following naloxone administration has often been ascribed to palatability or taste.
Unfortunately, many confounds become apparent when attempts are made to isolate such factors in the investigation of ingestive
behaviors. In the present study, rats (two groups) were trained to discriminate either a 10% or 5% sucrose solution from water
(0.1 ml). These mildly food deprived subjects (95% of free-feeding weight) were trained to press the appropriate lever in
a two-lever operant chamber following sampling of sucrose or water; successful responding was reinforced by delivery of a
45 mg grain food pellet. Following random exposure to reduced sucrose concentrations tested under extinction, a sucrose concentration
gradient (1.0, 0.5, 0.1, 0.05, 0.01 and 0.005% sucrose solution) was established for both training groups under IP saline
administration. Data collected under IP saline were then compared to those collected following random IP naloxone administration
(3.0, 1.0, 0.3 and 0.1 mg/kg). No significant differences were observed between the sucrose concentration gradients obtained
under saline and those obtained under naloxone, suggesting that the anorectic effect of naloxone is not primarily determined
by discrimination of sweet taste.
Received: 4 September 1996 / Final version: 16 October 1996 |
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Keywords: | Discrimination Naloxone Opioids Taste Sucrose |
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