地诺前列酮在足月妊娠引产中的应用效果观察

目的探讨地诺前列酮在足月妊娠引产中的应用效果。方法 110例有明显引产指征的初产妇按随机数字表法分为观察组和对照组,各55例。观察组给予地诺前列酮,对照组给予缩宫素。比较两组宫颈Bishop评分、分娩情况及不良反应。结果观察组用药后6 h的宫颈Bishop评分显著高于对照组,差异有统计学意义(P<0.05);观察组宫颈成熟总有效率高于对照组(96.36%vs78.18%),差异有统计学意义(P<0.01);两组剖宫产率、临产时间和总产程比较差异有统计学意义(P<0.05);两组不良反应情况比较差异无统计学意义(P>0.05)。结论与缩宫素相比,地诺前列酮用于足月妊娠引产能更好地促进宫颈成熟,改善分娩情况,且对母婴无不良影响,值得临床推广应用。

Clinical Observation of Dinoprostone in the Labor Induction of Full-term Pregnancy

Objective To investigate the effect of dinoprostone in the labor induction of full-term pregnancy.Methods 110 cases of primipara with obvious indications of labor induction were selected and divided into the observation group and control group with 55 cases in each group according to random number table.The observation group were given the dinoprostone,the control group were given oxytocin.The cervical Bishop score,delivery conditions and adverse reactions of the two groups were compared.Results The cervical Bishop scores of observation group were significantly higher than the control group at 6 h after drug using,the difference was statistically significant(P<0.05);the total effective rate of cervical ripening in the observation group was higher than the control group(96.36% vs 78.18%),the difference was statistically significant(P<0.01);the cesarean delivery,labor time and the total delivery process of observation group were significantly better than the control group,the differences were statistically significant(P<0.05);the adverse reactions had no significant difference between the two groups(P>0.05).Conclusion Compared to oxytocin,dinoprostone is better to promote cervical ripening and improve the labor conditions for labor induction in full-term pregnancy,and has no adverse effects on maternal and infant,thus is worthy of clinical application.