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| 环磷酰胺、长春新碱和泼尼松联合治疗51例非何杰金淋巴瘤 | |
| 引用本文： | 金杏泉,洪小南,俞鲁谊,孙曾一. 环磷酰胺、长春新碱和泼尼松联合治疗51例非何杰金淋巴瘤[J]. 中国新药与临床杂志, 1987, 0(4) |
| 作者姓名： | 金杏泉 洪小南 俞鲁谊 孙曾一 |
| 作者单位： | 上海医科大学附属肿瘤医院，上海医科大学附属肿瘤医院，上海医科大学附属肿瘤医院，上海医科大学附属肿瘤医院 上海 200032，上海 200032，上海 200032，上海 200032 |
| 摘 要： | 我们从1980年4月-1981年5月联合使用环磷酰胺、长春新碱和泼尼松(简称COP)治疗51例非何杰金淋巴瘤,25例(49％)达完全缓解,16例(31％)部分缓解,总缓解率80％。对影响疗效的因素,例如性别、组织病理类型、全身症状和临床分期进行讨论。COP联合方案毒副反应小,主要表现为轻-中度白细胞和血小板减少,可安全、广泛使用于门诊病人。 |
| 关 键 词： | 淋巴瘤 环磷酰胺 长春新碱 泼尼松 多剂联用抗肿瘤药 |
Treatment of 51 patients with non-Hodgkin''''s lymphoma with combined cyclophosphamide, vincristine and prednisone |
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| JIN Xing-Quan,HONG Xiao-Nan,YU Lu-Yi,SUN Zeng-Yi. Treatment of 51 patients with non-Hodgkin''''s lymphoma with combined cyclophosphamide, vincristine and prednisone[J]. Chinese Journal of New Drugs and Clinical Remedies, 1987, 0(4) | |
| Authors: | JIN Xing-Quan HONG Xiao-Nan YU Lu-Yi SUN Zeng-Yi |
| Abstract: | During 1980. 4-1981. 5, 51 patients (31M, 20F, aged 48?SD 15 yr) of non-Hodgkin's lymphoma were treated by COP regimen consisting of cyclophos-phamide 400-800 mg/wk iv. × 2-3wk, vincristine(Oncovin)l-2 mg/wk iv. × 2-3wk and prednisone 10 mg t. i. d. po. × 14-21 d. After 2 wk interval, the same course was repeated. Complete remission was obtained in 25 patients (49%) and partial remission in 16 patients (31%). Adverse drug reactions were mainly mild to moderate leucocytopenia and thrombo-cytopenia. The results showed that COP regimen was effective to non-Hodgkin's lymphoma and used safely in clinic. |
| Keywords: | lymphoma cyclophospha-mide vincristine prednisone combined antineoplastic agents |
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