尼莫地平对戊四氮致癫痫大鼠的抗氧化作用

目的探讨尼莫地平对实验性癫痫鼠的抗氧化作用.方法 50只Wistar大鼠随机分为5组,各10只.正常对照组：腹腔注射生理盐水;癫痫组：腹腔注射戊四氮（PTZ）50 mg/kg, 诱发癫痫后30 min处死;尼莫地平0.1、0.3、0.5 mg/kg 组：腹腔注射PTZ 50 mg/kg前15 min分别注射尼莫地平注射液0.1、0.3、0.5 mg/kg, 每隔24 h重复1次,连续3 d后处死.观察各组大鼠癫痫样发作的潜伏期、持续时间、发作形式,并测定各组大鼠脑组织超氧化物歧化酶（SOD）、丙二醛（MDA）、谷光甘肽过氧化物酶（GSH-PX）活性.结果尼莫地平预处理各组大鼠癫痫发作类型以轻型发作为主,发作潜伏期明显延长,持续时间短; SOD活性较癫痫组明显增高,MDA、GSH-PX活性明显下降,差异均有显著性（F＝10.720～35.831,P〈0.01）.结论尼莫地平可通过抗氧化机制来发挥抗癫痫作用.

ANTIOXIDANT EFFECT OF NIMODIPINE ON RATS WITH EPILEPSY INDUCED BY PENTETRAZOLE

ObjectiveTo explore the antioxidant role of nimodipine in experimental-epilepsy rats.MethodsFifty Wistar rats were divided into 5 groups: control group,epilepsy group,and 0.1 mg-,0.3 mg-,and 0.5 mg-nimodipine groups.The incubation period,duration,and the onset of epilepsy were observed and SOD,MDA,and GSH-PX of brain tissue were determined in the nimodipine group.The results were compared with those of the PTZ epilepsy group.ResultsThe onset in nimodipine-pretreatment group was characterized by light seizure,prolonged incubation time,short duration and high SOD, low MDA and GSH-PX.There were significantly difference between them(F=10.720-35.831,P<0.01).ConclusionAntiepileptic role of nimodipine may be achieved by its antioxidation.