The influence of aminotransferase levels on liver stiffness assessed by Acoustic Radiation Force Impulse Elastography: A retrospective multicentre study |
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| Authors: | Simona Bota Ioan Sporea Markus Peck-Radosavljevic Roxana Sirli Hironori Tanaka Hiroko Iijima Hidetsugu Saito Hirotoshi Ebinuma Monica Lupsor Radu Badea Carmen Fierbinteanu-Braticevici Ana Petrisor Mireen Friedrich-Rust Christoph Sarrazin Hirokazu Takahashi Naofumi Ono Fabio Piscaglia Sara Marinelli Mirela Danila |
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| Affiliation: | 1. Department of Gastroenterology and Hepatology, “Victor Babe?” University of Medicine and Pharmacy, Timisoara, Romania;2. Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Austria;3. Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan;4. Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan;7. Department of Internal Medicine 1, J.W. Goethe University Hospital, Frankfurt/Main, Germany;8. Department of Internal Medicine, Saga Medical School, Japan;9. Department of Gastroenterology, Eguchi Hospital, Mikaduki, Saga, Japan;10. Division of Internal Medicine, Department of Clinical Medicine, University and General Hospital S. Orsola-Malpighi, Bologna, Italy;11. Department of Radiology, University Hospital G.B. Rossi, University of Verona, Verona, Italy |
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| Abstract: | ![]()
BackgroundAcoustic Radiation Force Impulse Elastography is a new method for non-invasive evaluation of liver fibrosis.AimTo evaluate the impact of elevated alanine aminotransferase levels on liver stiffness assessment by Acoustic Radiation Force Impulse Elastography.MethodsA multicentre retrospective study including 1242 patients with chronic liver disease, who underwent liver biopsy and Acoustic Radiation Force Impulse. Transient Elastography was also performed in 512 patients.ResultsThe best Acoustic Radiation Force Impulse cut-off for predicting significant fibrosis was 1.29 m/s in cases with normal alanine aminotransferase levels and 1.44 m/s in patients with alanine aminotransferase levels > 5× the upper limit of normal. The best cut-off for predicting liver cirrhosis were 1.59 and 1.75 m/s, respectively.Acoustic Radiation Force Impulse cut-off for predicting significant fibrosis and cirrhosis were relatively similar in patients with normal alanine aminotransferase and in those with alanine aminotransferase levels between 1.1 and 5× the upper limit of normal: 1.29 m/s vs. 1.36 m/s and 1.59 m/s vs. 1.57 m/s, respectively.For predicting cirrhosis, the Transient Elastography cut-offs were significantly higher in patients with alanine aminotransferase levels between 1.1 and 5× the upper limit of normal compared to those with normal alanine aminotransferase: 12.3 kPa vs. 9.1 kPa.ConclusionLiver stiffness values assessed by Acoustic Radiation Force Impulse and Transient Elastography are influenced by high aminotransferase levels. Transient Elastography was also influenced by moderately elevated aminotransferase levels. |
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