舍曲林联合喹硫平对强迫症的疗效分析

目的评价舍曲林联合喹硫平治疗强迫症的疗效及安全性。方法采用Excel将96例符合《国际疾病分类(第10版)》(ICD-10)诊断标准的强迫症患者随机分为研究组和对照组各48例。研究组采用舍曲林联合喹硫平治疗,对照组单用舍曲林治疗,两组均治疗8周,于治疗前后采用耶鲁布朗强迫症状量表(Y-BOCS)和汉密尔顿焦虑量表(HAMA)评定疗效,采用药物不良反应量表(TESS)评估不良反应。结果治疗后,研究组总有效率高于对照组(95.83%vs.68.75%,P0.05);研究组Y-BOCS和HAMA评分均低于对照组,差异有统计学意义(8.4±1.6)分vs.(15.4±2.1)分、(6.5±1.1)分vs.(10.8±1.2)分,P均0.05];研究组与对照组不良反应发生率差异无统计学意义(6.25%vs.8.33%,P0.05)。结论舍曲林联合喹硫平治疗强迫症疗效优于单用舍曲林,安全性相当。

ficacy of sertraline combined with quetiapine in treatment of obsessive - compulsive disorder

Objective To investigate the efficacy and safety of sertraline combined with quetiapine in treatment of obsessive -compulsive disorder(OCD). Methods A total of 96 cases who met the criteria for OCD in International Classification of Diseases, tenth edition(ICD - 10)were randomly assigned to two groups based on excel program. Each group was 48 cases. The control group were treated with sertraline only,while the research group were treated with sertraline combined with quetiapine. Both groups were treated for 8 weeks. The efficacy was measured with the Yale - Brown Obsessive Compulsive Scale(Y - BOCS)and the Hamilton Anxiety Scale(HAMA). Adverse effects were assessed with Treatment Emergent Symptom Scale(TESS). Results In the total efficiency of the treatment,the research group was higher than the control group(95. 83% vs. 68. 75% ,P < 0. 05). The Y - BOCS and HAMA scores of the research group were both lower than those of the control group(8. 4 ± 1. 6)vs.(15. 4 ± 2. 1),(6. 5 ± 1. 1)vs. (10. 8 ± 1. 2),all P < 0. 05]. In addition,there was no statistical significant difference between the adverse reaction rates of the two groups(6. 25% vs. 8. 33% ,P > 0. 05). Conclusion Sertraline combined with quetiapine treatment has been found to be more effective in patients with OCD than alone with sertraline,while the safety is the same.