Species-specific activation of nuclear receptors correlates with the response of liver drug metabolizing enzymes to EMD 392949 in vitro |
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| Authors: | Stefan O. Mueller Yvonne Fery Gregor Tuschl Dieter Schrenk |
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| Affiliation: | 1. Merck KGaA, Merck Serono, Non-Clinical Development, Toxicology, 64297 Darmstadt, Germany;2. Institut für Angewandte Biowissenschaften, Karlsruhe Institute of Technology (KIT), Germany;3. University of Kaiserslautern, Food Chemistry and Toxicology, 67663 Kaiserslautern, Germany |
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| Abstract: | ![]()
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| Keywords: | AhR, arylhydrocarbon receptor bp, base pair DME, drug metabolizing enzyme DMEM, Dulbecco's modified Eagle's medium EMD, EMD 392949 FBS, fetal bovine serum nt, nucleotide(s) NXR, nuclear xenobiotic receptor P450, cytochrome P450-dependent monooxygenase PPAR, peroxisome proliferator-activated receptor PXR, pregnane X receptor SD, standard deviation v/v, volume per volume XRE, xenobiotic response element XREM, xenobiotic response enhancer module |
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