胃肠动力中药作用机制研究

中医学对胃肠运动障碍疾病的治疗有丰富的经验,且中药材药源丰富,副作用小,故运用中药治疗胃肠运动障碍疾病已逐渐得到重视.近年来人们对中药对胃肠动力的影响及其调节机制作了许多有益的探索,并提出了"胃肠动力中药"这一概念.有关研究表明,对胃肠运动功能有影响的中药可分为三类:促进胃肠运动、抑制胃肠运动、双向调节胃肠运动.通过整体实验、离体实验及整体结合离体实验研究显示,一些活血药、理气药具有促胃动力作用;而促肠运动的中药主要集中在润肠通便类或健脾消食类中药及复方中.其机制可以分为神经调节和脑肠肽调节等途径.但中药促胃肠运动的机制复杂而广泛,涉及胃肠运动的多个调节环节和因素,并且这些环节和因素之间存在着相互影响.目前研究中存在研究环节单一、检测指标少等问题,应注重多系统、多靶点地做全面系统的深入研究.

Study on the mechanism of traditional Chinese medicines in promoting gastrointestinal peristalsis

Traditional Chinese medicine has accumlated rich experience in treating dysfunction of gastrointestinal peristalsis. In recent years, a large number of studies have been made on the mechanism and effects of traditional Chinese medicines on the gastrointestinal peristalsis, and the concept of "gastrointestinal promoting Chinese medicine" has been advocated. These traditional Chinese medicines can be divided into three types: promoting the gastrointestinal peristalsis, inhibiting the gastrointestinal peristalsis, and bi-directional modulating. The in vivo and/or in vitro experiments showed that some of the traditional Chinese medicines for activating blood or regulating qi could promote the stomach peristalsis, and the traditional Chinese medicines for moistening intestines to relieve constipation or invigorating spleen to promote digestion could accelerate the intestinal peristalsis. The mechanism lies in the neuroregulation and gut-peptide regulation. Further research on multi-regulation and of multi-target should be done, for the mechanism of the traditional Chinese medicines in regulating the gastrointestinal peristalsis is far more complicated.