绞股蓝总甙复合国产1号避孕片对健康妇女脂类代谢及血压的影响

本研究将180名已婚、一孩、年龄33±5岁,需要使用避孕措施的健康妇女随机分成6组,即IUD组、绞股蓝总甙加IUD组、1号OC片组、40mg、60mg、80mg绞股蓝总甙分别与1号OC片复合的3个试验组.用双盲法给药,连续服用6个月观察脂类代谢和血压的变化.结果显示:以IUD组和1号OC片组的数据为参比值.服用不同剂量绞股蓝总甙复合口服避孕药后无升高TG和TC的趋势,有显著升高HDL-C作用和使APOA_1水平上升的趋势;亦存在降低收缩压的趋势,对舒张压无明显影响,但在服药后3个月时HDL-C水平曾发生暂时性下降.

Effects of Compound Containing Gypenosides with Chinese NO. 1 Contraceptive Pill on the Lipid Metabolism and Blood Pressure in Healthy Reproductive Women

This is an experimental study comparing the effect of clinical application in IUD group,use-ing gypenosides and dividing the cases into IUD group,IUD with gypenosides group,Chinese No. 1 contraceptive pill group and three experimental groups of compatible preparations of Chinese No. 1 contraceptive pill with three doses Gypenosides. 180 healthy women, who had one child, were 30?0 years old and needed to use contraceptive methods were randomly allocated to six groups. With drugs given to subjects double -blindedly , the changes of lipid metabolism and blood pressure were observed after use of drugs or IUD continuously for 6 months.The results show that the gypenosides has significant effects on decreasing triglycerides (TG) . increasing high density lipoprotein (HDL -C).rising apoliporotin (APOA_2) and reducing systolic pressure. With the data of IUD group and Chinese No. 1 pill group taken as referential values,the gypenosides compound oral contraceptive pill of different dose did not show a tendency to a rise in TG and total cholesterol (TO ,but had significant effect on increasing HDL -C,and a tendency to rise in APOA_1 and to reduce systolic pressure. without influence on diastolic pressure. Howevre,the level of HDL decreased temporally after use of drugs for 3 months.