过敏性紫癜细胞因子基因多态性的研究进展

过敏性紫癜（HSP）是儿童期较为常见的小血管性血管炎,其病因及发病机制尚不明确,近年来有研究表明某些细胞因子的基因多态性与HSP的发病机制、易感性、病理进展及预后等密切相关,如自细胞介素基因、细胞粘附分子基因、血管内皮生长因子基因、转化生长因子基因、肿瘤坏死因子基因等。因此对与HSP相关的细胞因子基因多态性进行综合分析将有着重要意义,为今后临床上从基因水平认识HSP疾病的本质及开发新的研究和新的治疗方案提供了重要的依据。

Research progress of gene polymorphism of cytokines with henoch-Sch(o)nlein purpura

Henoch-Schonlein purpura (HSP) is the most common vasculitis affecting mainly children and its etiology and pathogenesis are still unclear. In recent years, some studies have shown that the polymorphisms of certain cytokine genes, e. g. , Interleukin gene, cell adhesion molecule gene, vascular endothelial growth factor gene, transforming growth factor gene, etc. , are correlated with the pathogenesis, susceptibility, progress in pathology and prognosis of HSP. Therefore, comprehensive analysis of the association between cytokine gene polymorphisms and HSP would be important may provide clues for clinical to understanding the nature of HSP on the genetic level and new research and new treatment in future.