西南双生子登记系统:遗传因素与环境因素对儿童青少年行为发育及心理健康的影响研究

目的 描述西南双生子登记系统的目的 ,样本收集方法,目前现状以及应用前景.研究遗传因素和环境因素对于儿童青少年行为、认知发育以及心理健康的影响.方法 采用儿童自评、家长以及教师评定量表作为测量儿童行为和心理健康水平的工具,同时对儿童认知功能、家庭环境、儿童气质以及父母健康状况进行测评,研究上述指标与儿童行为的相互关系以及遗传因素和环境因素的影响.结果 目前已经登记了成都9339对0～16岁双生子,并对324对双生子进行了DNA卵型鉴定以及详细的行为和认知测评,并对遗传因素和环境因素对于儿童行为的相互影响进行了研究.结论 学校途径招募双生子是进行儿童青少年双生子研究有效的途径.西南双生子登记系统可以为儿童行为发育以及儿童病理心理研究提供重要的国内和国际资源.

A Prospective Twin Registry in Southwestern China: exploring the effects of genetic and environmental factors on cognitive and behavioral development and mental health well-being in children and adolescents

OBJECTIVE: The goals, prospects and methods of the Prospective Twin Registry in Southwestern China (TRiSC) are described. The aim of this study is to measure children's behavioral development and psychopathology from phenotypic, genetic and environmental perspectives. METHODS: The children's self-report, as well as parental and teachers' informant report were used to measure the children's behavior and psychopathology, and the latter was related to the children's general cognitive abilities, and to the parenting style. Other variables of interest such as children's temperament and parental health status were also used. RESULTS: Nine thousand and three hundred thirty nine pairs of 0-16 years old twins have been registered, 324 pairs of them were monozygotic based on DNA samples as well as the detailed information on behavioral and cognitive aspects.Analysis has been performed for the influences of genetic and environmental factors on children's behavior and cognition. CONCLUSION: School-based twins recruitment is a helpful method in child and adolescent twin study. TRiSC has been a valuable resource for research on the development of children's behavior and cognition.