| 扑热息痛直肠胶囊剂的溶出度和生物利用度研究 |
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| 引用本文： | 盛杰,郑志安,周嘉秀,姜宏颖,晏艳,葛启. 扑热息痛直肠胶囊剂的溶出度和生物利用度研究[J]. 药学实践杂志, 1995, 13(3): 161-164 |
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| 作者姓名： | 盛杰 郑志安 周嘉秀 姜宏颖 晏艳 葛启 |
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| 作者单位： | 空军兰州医院药剂科，兰州医药站，新疆金地市８７１４８部队卫生队 |
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| 摘 要： | ![]()
作者制备的扑热息痛直肠囊剂，可根据小儿体重分装成不同规格，便于临床实现个体化给药。本品与市售剂在家兔体内的达峰时分别为１．８７，１．６７ｈ；峰浓度及ＡＵＣ分别为５４．８６，４６．０９（ｍｇ／Ｌ）和１９８．９４，１８８．９４（ｍｇ．ｈ．Ｌ）。直肠胶囊剂用自行设计的“转筒膜法”测定，体外累积溶出百分率与体内吸收百分率间有显著相关性。
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| 关 键 词： | 扑热息痛 直肠胶囊剂 溶出度 生物利用度 |
Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene |
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| Sheng Jie,Zheng Zhian,Zhou Jiaxiu,Jiang Hongying,Yan Yan and Ge Qi. Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene[J]. The Journal of Pharmaceutical Practice, 1995, 13(3): 161-164 |
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| Authors: | Sheng Jie Zheng Zhian Zhou Jiaxiu Jiang Hongying Yan Yan Ge Qi |
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| Affiliation: | Department of Pharmacy, Lanzhou Airforce Hospital, 730070;Department of Pharmacy, Lanzhou Airforce Hospital, 730070;Department of Pharmacy, Lanzhou Airforce Hospital, 730070;Department of Pharmacy, Lanzhou Airforce Hospital, 730070;Department of Pharmacy, Lanzhou Airforce Hospital, 730070;Department of Pharmacy, Lanzhou Airforce Hospital, 730070 |
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| Abstract: | ![]()
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| Keywords: | acetaminophene rectal capsule dissolution bioavailability |
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