过氧化物酶体增殖物活化受体γ(PPARγ)与肝癌瘤内微循环的关系

Objective:To observe the association of the expression of peroxisome proliferator-activated receptor y (PPARy)with microvessel density (MVD) and vascularization mimicry (VM) in hepatocellular carcinoma (HCC) and explore their clinical significance.Methods:The expressions of PPARy and MVD and VM were tested by CD34 immunohistochemical (IHC) staining and periodic acid-Schiff (PAS) reaction in 34 cases of HCC tissues and its paired non-cancerous tissues.Their biological behaviors were analyzed and associated with the clinicopathological features.Results:PPARy was over-expressed (24/34)in HCC tissues.It was associated with tumor size (＞ 5 cm,P＝0.027),broken capsule (P＝0.014),tendency to metastasis and recurrence (P＝0.001).The MVD was higher (23/24) in HCC tissues than that in corresponding para-cancerous tissues (t＝18.925,P＜0.05).There was a significant positive correlation between the over-expression of PPARy and high MVD (r＝0.519).Kaplan-Meier analysis indicated that positive expression of PPARy and VM and high MVD could be used for predicating the survival rate of HCC patients (P＝0.013,0.036 and 0.022,respectively; log-rank test).Cox hazard model analysis showed that positive PPARy expression and high MVD were the independent prognostic factors for HCC.Conclusion:The PPARy correlated with the development of microcirculatory in HCC.PPARy is a novel prognostic indicator for evaluating of HCC.

Peroxisome proliferator-activated receptor γ expression correlates with tumor angiogenesis in human hepatocellular carcinoma

Objective  To observe the association of the expression of peroxisome proliferator-activated receptor γ (PPARγ) with microvessel density (MVD) and vascularization mimicry (VM) in hepatocellular carcinoma (HCC) and explore their clinical significance. Methods  The expressions of PPARγ and MVD and VM were tested by CD34 immunohistochemical (IHC) staining and periodic acid-Schiff (PAS) reaction in 34 cases of HCC tissues and its paired non-cancerous tissues. Their biological behaviors were analyzed and associated with the clinicopathological features. Results  PPARγ was over-expressed (24/34) in HCC tissues. It was associated with tumor size (> 5 cm, P = 0.027), broken capsule (P = 0.014), tendency to metastasis and recurrence (P = 0.001). The MVD was higher (23/24) in HCC tissues than that in corresponding para-cancerous tissues (t = 18.925, P < 0.05). There was a significant positive correlation between the over-expression of PPARγ and high MVD (r = 0.519). Kaplan-Meier analysis indicated that positive expression of PPARγ and VM and high MVD could be used for predicating the survival rate of HCC patients (P = 0.013, 0.036 and 0.022, respectively; log-rank test). Cox hazard model analysis showed that positive PPARγ expression and high MVD were the independent prognostic factors for HCC. Conclusion  The PPARγ correlated with the development of microcirculatory in HCC. PPARγ is a novel prognostic indicator for evaluating of HCC.