抗精神病药合并胰岛素低血糖与单纯抗精神病药治疗精神分裂症60例对照观察

本文报道了抗精神病药物合并胰岛素低血糖与抗精神病药物分组对照治疗女性精神分裂症病人(各30例)。用BPRS量表评分法和四级疗效标准评定为观察方法。结果提示,在即期疗效、好转方式,达到同一缓解水平所用治疗日数和抗精神病药的日使用量、BPRS总分和各因子分的减分幅度以及总分和除焦虑忧郁项以外的其它四项因子的减分速度等方面,合并治疗均无明显优点,其达显进疗效反而慢于对照组,而对焦虑忧郁症状的缓解较快于对照组。作者认为,从即期疗效上看,合并胰岛素低血糖疗法在精神分裂症治疗中无明显优势,应予淘汰。

Clinical Control Observation of Immediate Effect in 60 Schizophrenic patients Treated with Antipsychoties Combining with(and not)Insulin Hypoglycemic treatment

In this study 60 female schizo- phrenic patients were treated,Gr- oup A was treated with antipsych- otic drugs combining with insulin hypoglycemia,while group B was only treated with antipsychotic d- rugs,They were opserved by the rating methods of IV grade thera- peutic effect, The results show that in both groups there is no statistical sign- ificance in comparison of the imm- ediate effect,the feature of contr- olling the prominient psychiatric symptoms,the time needed for the same level of improvement,the d- aily-dose of antipsychotic drugs used,the lowering extent of the total counts and the count of each factor,the lowering speed of the total counts and the counts of fac- tors except anxiety-depression,the speed of having gotten prominient effect is slower in group A as co- mpared with group B,while the s- peed of having improved the anxi- ous and depressive symptoms is fa- ster in A as compared with B. The authors suggest that the t- herapy of antipsyehotic drugs com- bining with insulin hypoglycemic t- reatment on schizophrenia should be give up.