甄氏外瓶霉所致皮肤暗色丝孢霉病1例

患者女,57岁。右前臂伸侧出现红色斑块、溃疡5月余。皮损组织病理示:角化过度,表皮增生,真皮浅层及中层可见弥漫性以嗜中性粒细胞为主的混合炎性细胞浸润,伴红细胞渗出,真皮组织中存在真菌孢子及菌丝样结构。真菌种属鉴定示:甄氏外瓶霉。诊断:甄氏外瓶霉所致暗色丝孢霉病。伊曲康唑与特比萘芬口服联合治疗效果显著。

Cutaneous Phaeohyphomycosis Caused by Exophiala jeanselmei: A Case Report

A 57-year-old female had presented with red plaques and ulcers on her right forearm for more than 5 months. The histophathological examination showed hyperkeratosis, epidermal hyperplasia, diffuse infiltration of mixed inflammatory cells in the superficial and middle layers of the dermis, and exudation of erythrocytes. Furthermore, fungal spores and hyphae were found in the dermis of the skin lesion. The etiological agent was confirmed as Exophiala jeanselmei. The diagnosis of cutaneous phaeohyphomycosis caused by Exophiala jeanselmei was established. The skin lesion improved obviously after combined therapy with itraconazole and terbinafine for 4 months.