柳氮磺胺吡啶致重症药疹1例

患者男,57岁。全身皮肤红斑、瘀斑伴瘙痒、发热10d。患者1个月前因"溃疡性结肠炎"口服"柳氮磺胺吡啶",20d后全身皮肤出现红斑、瘀斑伴瘙痒、发热。血常规检查示单核细胞及嗜酸性粒细胞增多,血小板减少;肝功能异常;胸部CT平扫示腋窝淋巴结肿大。结合病史、临床表现和辅助检查诊断为:重症药疹。予甲基泼尼松龙联合人免疫球蛋白等治疗痊愈。

A Case of Sulfasalazine-induced Servere Drug Eruption

A 57-year-old male had presented with skin erythema, petechia accompanied by pruritus and fever for 10 days. The patient received the treatment for ulcerative colitis with sulfasalazine 1 month ago. After 20 days of treatment, the skin of trunk was affected by pruritic erythema, petechia with fever. Routine test of the blood showed increasing monocytes, eosinophils and thrombocytopenia. Liver function was impaired. Chest CT scan showed armpits lymph nodes enlargement. Diagnosed as Servere drug eruption based on medical history, clinical manifestations and results of laboratory test. The patient was cured by the treatment of Methylprednisolone combined Human immunoglobulin.