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汕头地区孕母产前血型抗体预测新生儿溶血病的研究
引用本文:邱小华,施冬梅,刘碧清,黄海花. 汕头地区孕母产前血型抗体预测新生儿溶血病的研究[J]. 实验与检验医学, 2014, 0(4): 401-402
作者姓名:邱小华  施冬梅  刘碧清  黄海花
作者单位:邱小华 (汕头大学医学院第二附属医院检验科,广东 汕头,515041); 施冬梅 (珠海市中心血站,广东 珠海,519040); 刘碧清 (汕头市第二人民医院检验科,广东 汕头,515041); 黄海花 (汕头大学医学院第二附属医院病理科,广东 汕头,515041);
基金项目:广东省卫生厅基金项目(编号A2013409);汕头市医疗重点科技计划项目资助,项目(项目编号:汕府科[2012]113号。)
摘    要:目的:探讨本地区ABO血型不合孕妇产前抗体效价检测在预测新生儿溶血病(HDN)中的意义。方法对536名血型不合的O型及Rh阴性孕妇在妊娠20周时进行血型不规则抗体筛选,抗体效价检测,效价≥64的定期(每4周)进行血型抗体效价复查检测,对新生儿出生后(0-7d)出现黄疸症状的抽静脉血3 ml进行血型血清学和溶血病三项检测。结果在536名孕妇血清中检出血型抗体303例,占56.5%,其中IgG抗体≥64者175例,占32.6%;,7名Rh阴性孕妇血清中产生抗D抗体3例,占0.6%;新生儿发生黄疸303例,诊断HDN 73例,占24.1%,接受治疗后均痊愈出院。结论汕头地区孕母产前血型抗体效价与新生儿溶血病密切相关,定期筛选与测定孕母体内血型抗体效价可预测HDN的发生,评估HDN的严重程度及提高HDN的治愈率。

关 键 词:新生儿溶血病  血型抗体  新生儿黄疸

The value of pregnant woman blood group antibody in predicting of neonatal hemolysis disease in Shantou area
Affiliation:QIU Xi- aohua, SHI Dongmei, LIU Biqing, et al.( Department of Laboratory Medicine, the Second Affiliated Hospital, Medical College of Shantou University, Shantou Guangdong 515041, China.)
Abstract:Objective To investigate the value of ABO antibody titer of pregnant women with ABO blood group incompatibili-ty in predicting of hemolytic disease of the newborn (HDN). Methods A total of 536 pregnant women with ABO blood group in-compatibility and Rh negative were selected. At 20 weeks of gestation, blood group antibody titer was detected. The women with titer ≥64 were rechecked every 4 weeks until delivery. The newborns with jaundice in 0-7 days after birth were checked with blood group and hemolysis diseases test. Results In 536 cases, 303 pregnant women had blood group antibody, accounting for 56.5%. 175 cases had IgG antibody titer≥64, accounting for 32.6%. In 7 cases with Rh negative, 3 women (0.3%) were tested with D antibody. In 303 newborns with neonatal jaundice, 73 cases were proofed with HDN, and all of them were recovered. Con-clusion The pregnant woman blood group antibody is closely related to HDN in Shantou area. Regular screening of blood group an-tibody titer in pregnant women is very important for predicting the occurrence and the severity of HDN, and improving the cure rate of HDN.
Keywords:Neonatal hemolysis  Blood group antibody  Neonatal jaundice
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