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| HPLC法测定降脂宁胶囊中槲皮素的含量 | |
| 引用本文： | 林瑞红,黄顺旺,曹明成.HPLC法测定降脂宁胶囊中槲皮素的含量[J].中国药房,2008,19(9):687-688. |
| 作者姓名： | 林瑞红 黄顺旺 曹明成 |
| 作者单位： | 1. 沈阳市药品快速检验所,沈阳市,110013 2. 合肥仁康医药科技有限公司,合肥市,230088 3. 合肥仁康医药科技有限公司,合肥市,230088;沈阳药科大学现代社会药学研究中心,沈阳市,110016 |
| 摘 要： | 目的:建立以高效液相色谱法测定降脂宁胶囊中槲皮素含量的方法。方法:色谱柱为Shim-packVP-ODSC18(150mm×4·6mm,5μm),流动相为甲醇-0·4%磷酸溶液(52:48),流速为0·8mL·min-1,检测波长为373nm。结果:槲皮素的进样量在0·0189～0·0566μg范围内与峰面积积分值呈良好的线性关系(r=0·9999);平均回收率为98·06%,RSD=1·73%(n=6)。结论:本方法简便、可靠、准确,可用于降脂宁胶囊的质量控制。 |
| 关 键 词： | 降脂宁胶囊 槲皮素 高效液相色谱法 含量测定 |
| 文章编号： | 1001-0408（2008）09-0687-02 |
| 收稿时间： | 2007-05-14 |
| 修稿时间： | 2007-12-22 |
Determination of Quercetin in Jiangzhining Capsules by HPLC |
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| LIN Rui-hong,HUANG Shun-wang,CAO Ming-cheng.Determination of Quercetin in Jiangzhining Capsules by HPLC[J].China Pharmacy,2008,19(9):687-688. | |
| Authors: | LIN Rui-hong HUANG Shun-wang CAO Ming-cheng |
| Institution: | LIN Rui-hong,HUANG Shun-wang, CAO Ming-cheng,CAO Ming-cheng(1Shenyang Institute of Quick Drug Inspection, Shenyang 110013,China;2Hefei Renkang Pharmaceutical Science and Technology Co. Ltd., Hefei 230088, China;3Research Center for Modern Social Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China) |
| Abstract: | OBJECTIVE： To establish an HPLC method for the determination of the content of Quercetin in Jiangzhining capsules. METHODS： The chromatographic column was Shim- pack VP- ODS C18（150 mm × 4.6 mm, 5 μm） .The mobile phase was methanol - 0.4% phosphoric（52 ： 48） at a flow rate of 0.8 mL · min^ -1.The detection wavelength was 373 nm. RESULTS： The linear range of Quercetin was 0.018 9-0.056 6 μg （r = 0.999 9）, with its average recovery rate at 98.06% （RSD = 1.73%, n = 6） .CONCLUSION： The method is simple, reliable and accurate, and suitable for the quality control of Quercetin in Jiangzhining capsules. |
| Keywords: | Jiangzhining capsules Quercetin HPLC Content determination |
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