经皮微波消融活体兔肺的实验研究

目的探讨经皮微波消融活体肺组织的有效性及安全性。方法在CT引导下经皮微波消融7只新西兰大白兔的肺组织。消融后即刻处死2只实验动物,观察组织微波消融后的病理变化;其余5只实验动物分别于消融后1周、3个月复查CT。结果术后即刻CT扫描,消融区直径1.1～1.6cm;1周后范围略有缩小;3个月后明显缩小,甚至消失。2只实验动物出现少量气胸,未经治疗,1周后复查已自愈。微波消融后组织病理学改变的特点是中央坏死和周围组织水肿。结论经皮微波消融活体兔肺是安全的,它有望成为治疗肺肿瘤的微创、有效的方法。

CT-guided percutaneous microwave ablation of lung: a preliminary study

Objective To assess the feasibility and safety of percutaneous microwave ablation of the lung in rabbits.Methods Percutaneous puncture and lung microwave ablation were performed in seven new zealand white rabbits under computed tomography(CT) guidance.Technical feasibility and complications were evaluated.Two rabbits were sacrificed immediately,and gross and microscopic pathology was analyzed.The remaining rabbits received CT scans 1 week and 3 months later.Results CT scans showed the ablation size was 1.1~1.6 cm immediately after ablation.The lesions shrank slightly 1 week later.After 3 months,the ablation lesions involuted significantly and even disappeared.Mild pneumothorax was found in 2 rabbits but resolved spontaneously 1 week later.Histologic changes in the microwave lesions were observed,which were characterized by the central necrosis and edema of surrounding tissues.Conclusion It is feasible and safe to perform CT-guided percutaneous microwave ablation of the lung in rabbits.Although further study is still required,this method can be used as a minimally invasive and effective therapeutic technique in patients with lung tumors.