心肌缺血的左室舒张功能改变

本文对结扎冠状动脉前降支的实验动物与冠心病患者用多普勒超声心动图（ＰＤＥ）作左室舒张功能测定，同时对实验动物作心导管测压。发现结扎前降支后ＬＡＰ及ＬＶＥＤＰ增高，—ｄｐ／ｄｔ下降，两组ＰＤＥ均显示左室流入道正峰降低，Ａ峰增高。其ＥＤＣ的下降与梗塞心肌重量（动物组）相关佳；０．５Ａ／ＴＡ及０．３３Ａ／ＴＡ，ＥＤＣ的改变随病变血管数增多而下降显著（临床组）。故上述指标对冠心病的诊断与预后评定有一定价值。

The Research of Left Ventricular Diastolic Function in Ischemic Heart

The left ventricular diastolic functions were studied by PDE in 12-cases of experimentalsheep with their LAD coronary artery ligated,and 78-cases of ischemic heart disease patients proved by coronaryartery angiography.In experimental groups,the pressure within heart chamber was measured simutaneously.Af-ter occlution,LAP,LVEDP were elevated,-dp/dt was decreased.EDE showed the peak E decreased and peakA increased in left ventricular inlet tract both in animals and patlents.In experimental group a good correlationwas shown between the decreased EDC and infarct cardiac mass.In clinical group,EDC 0.5A/TA,0.33A/TAwere changed obviously,the P value was increased followed the increase of impaired vesxel number.We suppoxed these indexes had certain value in diagnosis and prcdicting prognosis of ischemic heart disease.