血浆降钙素原联合C反应蛋白和白细胞计数检测在呼吸道感染中的应用

目的 探讨血浆降钙素原（PCT）、C反应蛋白（CRP）和白细胞计数（WBC）联合检测在诊断呼吸道感染中的作用.方法 应用电化学发光法检测PCT,在CRP分析仪上快速检测CRP,在全自动血球仪上检测WBC,对呼吸道感染组和健康对照组分别检测.结果 感染组PCT、CRP、WBC均明显高于健康对照组,差异有统计学意义（P〈0.01）.细菌性感染患者血浆PCT、CRP、WBC水平明显升高,而非细菌性感染患者血浆中PCT、CRP、WBC水平正常或轻度升高,两者之间差异有统计学意义（P〈0.01）.PCT、CRP以及WBC联合测定,敏感性可达87.8%,特异性为93.5%.结论 三者联合检测可以提高临床检测率,有利于鉴别诊断,有助于抗生素的合理使用.

The application of combined detection of PCT,CRP and WBC in respiratory infection patients

Objective To investigate the procalcitonin（PCT） ,C reactive protein（CRP） and leukocyte count（WBC） joint detec- tion application in the diagnosis of respiratory tract infection. Methods Electrochemical luminescence method was applicated in the detection of PCT. CRP was detected by CRP rapid analyzer, and WBC was detected by automatic whole blood corpuscle instrument. Results The levels of PCT,CRP and WBC in infection group were significantly higher than those in normal control group（P〈0.01）. Compared with non-bacterial infection patients, the levels of PCT, CRP and WBC in bacterial infection patients increased sig- nificantly（P〈0.01）. When the levies of PCT,CRP and WBC were detected jointly,the sensitivity was up to 87.8%,with the speci- ficity of 93.5%. Conclusion Combined detection can improve clinical detection rate,which is heipul for differential diagnosis and reasonable drug treatment.