胱抑素C检测在新生儿窒息早期肾功能损伤中的应用

目的 研究新生儿窒息时胱抑素C（CysC）与尿素氮（BUN）、肌酐（Cr）3个指标在早期肾功能损伤的诊断价值.方法 临床诊断为窒息新生儿及正常新生儿分别采静脉血用酶法检测BUN、Cr、及免疫比浊法检测CysC（127例）.结果 轻度窒息组CysC均值为1.77 mg/L阳性率为83.73%（36/43）;重度窒息组CysC均值为2.17 mg/L阳性率为91.18%（31/34）;对照组CysC均值为1.45 mg/L,阳性率为8.00%（4/50）;窒息组与对照组相比差异有统计学意义（P〈0.05）.轻度窒息组BUN阳性率6.98%（3/43）、Cr阳性率为16.29%（7/43）;重度窒息组BUN阳性率11.77%（4/34）、Cr阳性率为17.65%（6/34）;对照组BUN阳性率6.00%（3/50）、Cr阳性率为8.00%（4/50）;经统计分析BUN、Cr各组间差异均无统计学意义（P〉0.05）.结论 CysC是目前反映早期肾功能损伤较好的指标,能为临床早期诊断治疗提供依据.

The association between early renal damage caused by neonatal asphyxia and CysC

Objective to study the neonatal asphyxia in inhibition C（CysC） and urea nitrogen（BUN）, creatinine（Cr） to assess the diagnostic value of three indicators in early renal injury. Methods Blood samples from patients with clinical diagnosis of as- phyxia newborn and normal newborns venous were collected. BUN and Cr were detected by enzymatic mathod, and CysC was detec- ted by immune turbidimetric method. Results The CysC average levels of mild asphyxia group,severe asphyxia group,and control group were 1.77,2.17,and 1.45 mg/L,and the positive rates were 83.73%（36/43）,91.18%（31/34） ,and 8.00% （4/50）,respec- tively. There was significant difference between asphyxia group and control group（P〈0.05）. The positive rates of BUN and Cr in mild asphyxia group were 6.98% （3/43） and 16.29% （7/43）, respectively,which were 11.77% （4/34） and 17.65% （6/34） in se- vere asphyxia group. And there were 3 BUN positive cases（6.00% ,3/50） and 4 Cr positive cases（8.00% ,4/50） in control group. There was no significant difference of BUN and Cr among the groups（P〉0.05）. Conclusion CysC is a good index reflecting the early renal damage,which can provide basis for early clinical diagnosis and treatment.