中药罗汉果抗血脂紊乱的实验研究

目的观察中药罗汉果对实验性血脂紊乱SD大鼠血清总胆固醇(TC)、低密度脂蛋白(LDL-c)、三酰甘油(TG)及高密度脂蛋白(HDL-c)水平的影响。方法 50只雄性SD大鼠(体质量180g-220g)适应性饲养7d后随机分为空白对照组和造模组,造模组上午8时至下午18时给予普通饲料喂养,18时至次日上午8时高脂饲料喂养,共4周。4周后禁食12h断尾采血测两组空腹血清TC、LDL-c、TG、及HDL-c水平,造模组血脂各指标显著升高具有统计学意义者,确定为模型建立成功。将造模成功的模型组大鼠再随即分为药物实验组(20只,给予含生药4g/(kg d)罗汉果水溶液灌胃)和模型对照组(20只),后者继续高脂饲料喂养。至第八周后测血清TC、LDL-c、TG、及HDL-c水平。结果实验组血清TC)和LDL-c)的水平显著低于对照组(P<0.05);TG水平较对照组有下降趋势,HDL-c水平较对照组有上升趋势。结论中药罗汉果可显著降低实验大鼠血清TC和LDL-c,可通过调节血脂代谢紊乱发挥抗动脉粥样硬化作用。

Experimental Study of Chinese Medicine Luohanguo Anti-dyslipidemia

Objective To study the effect of Momordica grosvenori Swingle （MGS） anti- abnormal lipid metabolism in experimental rats. Methods Fifty SD healthy male rats weighing 180g-220g were fed for a week before randomization divideding into control group （n = 10） and model group, i.e. the high lipid roup （n = 40） . The control group was given general fodder, the model group was given general fodder from 8：00 am to 18：00 pm and fed high fat diet from 18：00 pm to 8：00 am of the next day for 4 weeks. After 4 weeks, the blood lipid were tested by cut the tails of the rats after 12 hours of fasting, inkluding the serum total cholesterol （TC） , low-density lipoprotein cholesterol （LDL-c） , triglyceride （TG） and high-density lipoprotein cholesterol （HDL-c） in each group. If the the lipid blood lipid were significant higher in the model group than that of the control group, it means that the lipid disorder model of the rats were successfully created, and then, the model group was subdivided into model test group that was given the MGS medecine （n=20, crude drug 4g/ （kgod） ] by intra-gastrically and model control group （n=20） was given high fat diet continuously but no medecine for another 4weeks. After another 4 weeks the blood lipid was examed again. Results The TC, LDL-c, TG was significantly higher and HDL-C significantly lower in model group compared to that of the control group （P〈0.05） , The TC, LDL-c decreased significantly in model test group than that of model control group （P〈 0.05） , while The TG showed decreasing and The HDL-c increasing but not reach the tstatistical significance （P〉0.05） . Conclusion The Chinese herbs medicine Momordica grosvenori Swingle has the effect of lowering hyperlipidemia and can be used as a medicine for antiatherosclerosis.