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| 肿瘤分子靶向治疗药物耐药机制研究进展 | |
| 引用本文： | 张静,曹水,任秀宝. 肿瘤分子靶向治疗药物耐药机制研究进展[J]. 国际免疫学杂志, 2011, 34(3): 195-197. DOI: 10.3760/cma.j.issn.1673-4394.2011.03.008 |
| 作者姓名： | 张静 曹水 任秀宝 |
| 作者单位： | 天津医科大学附属肿瘤医院生物治疗科天津市肿瘤防治重点实验室,天津,300060 |
| 基金项目： | 天津市应用基础及前沿技术研究计划 |
| 摘 要： | 肿瘤分子靶向治疗药物主要分为单靶点药物和多靶点药物,两者在肿瘤临床治疗中都取得了良好的治疗效果,但临床研究发现即使最初对靶向药物表现出良好反应性的患者,在经过一段时间有效期后都会出现耐药性.因此,研究耐药性的机制对预防或延缓耐药性的出现至关重要.研究发现,不管是单靶点药物还是多靶点药物,其耐药机制主要可以概括为以下几个... |
| 关 键 词： | 肿瘤 分子靶向治疗 耐药机制 |
Progress in drug-resistance mechanisms of molecular targeted agents |
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| ZHANG Jing,CAO Shui,REN Xiu-bao. Progress in drug-resistance mechanisms of molecular targeted agents[J]. International Journal of Immunology, 2011, 34(3): 195-197. DOI: 10.3760/cma.j.issn.1673-4394.2011.03.008 | |
| Authors: | ZHANG Jing CAO Shui REN Xiu-bao |
| Affiliation: | ZHANG Jing, CAO Shui, REN Xiu- bao. (Key Laboratory of Cancer Prevention and Therapy of Tianfin ; Department of Cancer Biotherapy, Affiliated Tumor Hospital, Tianfin Medical University, Tianfin 300060, China ) |
| Abstract: | Molecular-targeted therapy is a newly developed approach for cancer therapy. Molecular-targeted drugs include mono- targeted and multi-targeted agents. Both of them play an important role in cancer therapy. However,patients who initially respond to targeted-drugs may result in disease progress. Therefore,it is of significance to study drug-resistance mechanisms in the application of molecular targeted agents. We summarize in this review that these mechanisms may include second mutation of targeted gene, the activation of other signal pathway and the effect of some cellular factors. |
| Keywords: | Carcinoma Molecular-targeted therapy Drug-resistance mechanism |
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