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| Th17细胞及其细胞因子在肺部感染中的作用 | |
| 引用本文： | 李阿敏,崔学范. Th17细胞及其细胞因子在肺部感染中的作用[J]. 国际免疫学杂志, 2011, 34(3): 201-203,208. DOI: 10.3760/cma.j.issn.1673-4394.2011.03.010 |
| 作者姓名： | 李阿敏 崔学范 |
| 作者单位： | 南京医科大学第一附属医院呼吸科,210029 |
| 摘 要： | Th17细胞是CD4+T细胞的一个亚型,最近几年对其研究较多,它能分泌多种细胞因子,主要有IL-17A、IL-17F、IL-22、IL-26和IFN-γ.其中IL-17和IL-22在肺部抗感染方面发挥了重要作用.肺黏膜抗胞外菌特别是革兰氏阴性菌感染过程中,IL-17和IL-22一方面能促进抗微生物肽(防御素)的生成,另... |
| 关 键 词： | Th17细胞 IL-17 IL-22 防御索 肺部感染 |
The effect of Th17 cells and their cytokines in pulmonary infection |
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| LI A-min,CUI Xue-fan. The effect of Th17 cells and their cytokines in pulmonary infection[J]. International Journal of Immunology, 2011, 34(3): 201-203,208. DOI: 10.3760/cma.j.issn.1673-4394.2011.03.010 | |
| Authors: | LI A-min CUI Xue-fan |
| Affiliation: | .( Department of Respiratory, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China) |
| Abstract: | Th17 cells are a distinct lineage of proinflammatory CD4+ T helper cells. Researches have demonstrated that these cells could express various kinds of cytokines,such as IL-17A,IL-17F,IL-17C,IL-22,IL-26 and interferon-γ. IL-17 and IL-22 play an important role in resisting pathogens especially pulmonary Gram-negative bacteria. They could promote the defensins release and regulate the generation of multiple cytokines, such as IL-8, chemotatic factor CXC and granulocyte colony-stimulating factor(G-CSF). Therefore,they can augment neutrophil infiltration in the sites of infection. In addition, IL-22 increased lung epithelial cell proliferation and transepithelial resistance to injury. Moreover, the anti-infection effects of these two cytokines are synergistic and in feedback manner, which are important in the clearamce of pathogens and the maintenance of lung homeostasis. |
| Keywords: | IL-17 IL-22 |
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