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| 芦氟沙星凝胶的研制 | |
| 引用本文： | 罗毅,潘细贵,马俊玲,罗顺德. 芦氟沙星凝胶的研制[J]. 中国医院药学杂志, 2001, 21(2): 90-92 |
| 作者姓名： | 罗毅 潘细贵 马俊玲 罗顺德 |
| 作者单位： | 武汉大学人民医院, |
| 摘 要： | 目的：研制一种局部应用的经皮给药制剂芦氟沙星凝胶，方法：以卡波姆－940为凝胶基质制备了芦氟沙星凝胶，建立了性状，酸碱度，含量测定等质控方法，并进行了稳定性和皮肤刺激性试验，结果：以HPLC法测定芦氟沙得含量平均回收率为100．45％，RSD为0．96％（n=5），凝胶稳定性良好，结论：该制剂制备工艺可行，性质稳定，质控方法简单可靠。 |
| 关 键 词： | 芦氟沙星 凝胶剂 质量控制 三环氟喹诺酮类 |
| 文章编号： | 1001-5213(2001)02-0090-03 |
| 修稿时间： | 2000-04-09 |
Study on rufloxacinhydrochloride gel |
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| LUO Yi,PAN Xi-Gui,MA Jun-Ling,et al. Study on rufloxacinhydrochloride gel[J]. Chinese Journal of Hospital Pharmacy, 2001, 21(2): 90-92 | |
| Authors: | LUO Yi PAN Xi-Gui MA Jun-Ling et al |
| Abstract: | OBJECTIVE:To prepare rufloxacin hydrochloride gel.METHODS:Carbopol-940 was used as the gel stroma.Quality control method for the gel was established,stability tests and skin irritating tests were performed.RESULTS:The content of Rufloxacin hydrochloride was determined by HPLC method with an average recovery of< 100.45% (RSD= 0.96% ).The gel is stable.CONCLUSIONS:The gel can be prepared feasibly.The quality of the gel can be controlled easily. |
| Keywords: | Rufloxacin hydrochloride Gel quality control |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |