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| C—myc基因在人类染色体上的定位 | |
| 引用本文： | 张福泉,范洪学,刘晓秋,王立华,凌翎,刘及. C—myc基因在人类染色体上的定位[J]. 吉林大学学报(医学版), 1991, 0(1) |
| 作者姓名： | 张福泉 范洪学 刘晓秋 王立华 凌翎 刘及 |
| 作者单位： | 白求恩医科大学预防医学院环境病理教研室(张福泉，范洪学，刘晓秋，王立华，凌翎)，白求恩医科大学预防医学院环境病理教研室(刘及) |
| 摘 要： | 本文应用染色体原位杂交方法对c-mye基因在人类染色体上的位置进行定位研究。结果表明,在100个正常人染色体分裂相中,38％的杂交银粒位于8号染色体上,其中80％在8q24位置。在其它染色体上,杂交银粒随机分布。c-myc基因的激活在许多人类肿瘤的形成和发展中起重要作用。研究其在正常及恶变细胞中位置的变化,为探讨癌变机理,诊断肿瘤,防止癌的形成提供依据。 |
| 关 键 词： | 染色体原位杂交 癌基因 易位基因定位 缺口翻译 |
CHROMOSOIVIAL LOCALIZATION OF C-MYC GENE IN MAN |
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| Chang Fuquan,et al. CHROMOSOIVIAL LOCALIZATION OF C-MYC GENE IN MAN[J]. Journal of Jilin University: Med Ed, 1991, 0(1) | |
| Authors: | Chang Fuquan et al |
| Affiliation: | School of Preventive Medicine |
| Abstract: | We used in situ the chromosome hybridization techniques to map the cellular oncogene c-myc on human chromosomes, and found that grains were distributed randomly in various regions, except chromosome 8 . Thirty-eight per cent of the grains were found on chromosome 8 , essentially (80%) at band q24. Ac-tivated c-myc gene plays an important role in transformation and development of neoplasia. Direct study on the location of c-myc gene in normal and malignant cells can contribute to understanding of the mechanism of tumorigenesis, prevention of cancer and development of more effective anti-cancer agents. |
| Keywords: | In situ chromosome hybridization Oncogene Geue mapping Nick-translation Chromosomal translocation |
| 本文献已被 CNKI 等数据库收录！ | |